Prediction of the pharmacokinetics, pharmacodynamics and efficacy of a monoclonal antibody, using a physiologically based pharmacokinetic FcRn model.

by Manoranjenni eChetty, Linzhong eLi, Rachel eRose, Krishna eMachavaram, Masoud eJamei, Amin eRostami-Hodjegan, Amin eRostami-Hodjegan, Iain eGardner
Published 2015-01-01

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug conc...

by Manoranjenni eChetty, Rachel eRose, Khaled eAbduljalil, Nikunjkumar ePatel, Gaohua eLu, Theresa eCain, Masoud eJamei, Amin eRostami-Hodjegan, Amin eRostami-Hodjegan
Published 2014-11-01