Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains

by Dawid Deneka, Sonja Rutz, Cedric A. J. Hutter, Markus A. Seeger, Marta Sawicka, Raimund Dutzler
Published 2021-09-01

Exploring conformational equilibria of a heterodimeric ABC transporter

by M Hadi Timachi, Cedric AJ Hutter, Michael Hohl, Tufa Assafa, Simon Böhm, Anshumali Mittal, Markus A Seeger, Enrica Bordignon
Published 2017-01-01

An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification

by Hongmin Cai, Hebang Yao, Tingting Li, Cedric A. J. Hutter, Yanfang Li, Yannan Tang, Markus A. Seeger, Dianfan Li
Published 2020-12-01

Kinetic mechanism of Na+-coupled aspartate transport catalyzed by GltTk

by Gianluca Trinco, Valentina Arkhipova, Alisa A. Garaeva, Cedric A. J. Hutter, Markus A. Seeger, Albert Guskov, Dirk J. Slotboom
Published 2021-06-01

Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders.

by Markus A Seeger, Anshumali Mittal, Saroj Velamakanni, Michael Hohl, Stefan Schauer, Ihsene Salaa, Markus G Grütter, Hendrik W van Veen
Published 2012-01-01

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5

by Kevin Bärlocher, Cedric A. J. Hutter, A. Leoni Swart, Bernhard Steiner, Amanda Welin, Michael Hohl, François Letourneur, Markus A. Seeger, Hubert Hilbi
Published 2017-11-01

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

by Thomas Eicher, Markus A Seeger, Claudio Anselmi, Wenchang Zhou, Lorenz Brandstätter, François Verrey, Kay Diederichs, José D Faraldo-Gómez, Klaas M Pos
Published 2014-09-01

A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

by Jessica Hartmann, Robert C. Münch, Ruth-Therese Freiling, Irene C. Schneider, Birgit Dreier, Washington Samukange, Joachim Koch, Markus A. Seeger, Andreas Plückthun, Christian J. Buchholz
Published 2018-09-01

A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

by Jessica Hartmann, Robert C. Münch, Ruth-Therese Freiling, Irene C. Schneider, Birgit Dreier, Washington Samukang, Joachim Koch, Markus A. Seeger, Andreas Plückthun, Christian J. Buchholz
Published 2021-06-01

The extracellular gate shapes the energy profile of an ABC exporter

by Cedric A. J. Hutter, M. Hadi Timachi, Lea M. Hürlimann, Iwan Zimmermann, Pascal Egloff, Hendrik Göddeke, Svetlana Kucher, Saša Štefanić, Mikko Karttunen, Lars V. Schäfer, Enrica Bordignon, Markus A. Seeger
Published 2019-05-01

Synthetic single domain antibodies for the conformational trapping of membrane proteins

by Iwan Zimmermann, Pascal Egloff, Cedric AJ Hutter, Fabian M Arnold, Peter Stohler, Nicolas Bocquet, Melanie N Hug, Sylwia Huber, Martin Siegrist, Lisa Hetemann, Jennifer Gera, Samira Gmür, Peter Spies, Daniel Gygax, Eric R Geertsma, Roger JP Dawson, Markus A Seeger
Published 2018-05-01

A multidrug ABC transporter with a taste for salt.

by Saroj Velamakanni, Calvin H F Lau, Daniel A P Gutmann, Henrietta Venter, Nelson P Barrera, Markus A Seeger, Barbara Woebking, Dijana Matak-Vinkovic, Lekshmy Balakrishnan, Yao Yao, Edmond C Y U, Richard A Shilling, Carol V Robinson, Peter Thorn, Hendrik W van Veen
Published 2009-07-01

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

by Tânia F. Custódio, Hrishikesh Das, Daniel J. Sheward, Leo Hanke, Samuel Pazicky, Joanna Pieprzyk, Michèle Sorgenfrei, Martin A. Schroer, Andrey Yu. Gruzinov, Cy M. Jeffries, Melissa A. Graewert, Dmitri I. Svergun, Nikolay Dobrev, Kim Remans, Markus A. Seeger, Gerald M. McInerney, Ben Murrell, B. Martin Hällberg, Christian Löw
Published 2020-11-01

A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection

by Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. Seeger, Yao Cong, Barry Rockx, Gary Wong, Yuhai Bi, Dimitri Lavillette, Dianfan Li
Published 2021-07-01