Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Diff...

by Thomas Ondet, Pierre-François Roux, Mario Monshouwer, Georgios N. Stamatas
Published 2021-06-01

EGFR inhibitors switch keratinocytes from a proliferative to a differentiative phenotype affecting epidermal development and barrier function

by Nicolas Joly-Tonetti, Thomas Ondet, Mario Monshouwer, Georgios N. Stamatas
Published 2021-01-01

Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture

by Nora Freyer, Selina Greuel, Fanny Knöspel, Nadja Strahl, Leila Amini, Frank Jacobs, Mario Monshouwer, Katrin Zeilinger
Published 2017-08-01

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

by Fanny Knöspel, Frank Jacobs, Nora Freyer, Georg Damm, An De Bondt, Ilse van den Wyngaert, Jan Snoeys, Mario Monshouwer, Marco Richter, Nadja Strahl, Daniel Seehofer, Katrin Zeilinger
Published 2016-04-01

Prediction of the drug–drug interaction potential of the α1‐acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib

by Loeckie De Zwart, Jan Snoeys, Frank Jacobs, Lilian Y. Li, Italo Poggesi, Peter Verboven, Ivo Goris, Ellen Scheers, Inneke Wynant, Mario Monshouwer, Rao N. V. S. Mamidi
Published 2021-09-01

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

by Ruben Boon, Manoj Kumar, Tine Tricot, Ilaria Elia, Laura Ordovas, Frank Jacobs, Jennifer One, Jonathan De Smedt, Guy Eelen, Matthew Bird, Philip Roelandt, Ginevra Doglioni, Kim Vriens, Matteo Rossi, Marta Aguirre Vazquez, Thomas Vanwelden, François Chesnais, Adil El Taghdouini, Mustapha Najimi, Etienne Sokal, David Cassiman, Jan Snoeys, Mario Monshouwer, Wei-Shou Hu, Christian Lange, Peter Carmeliet, Sarah-Maria Fendt, Catherine M. Verfaillie
Published 2020-03-01