The benign c.344G > A: p.(Arg115His) variant in the LDLR gene interpreted from a pedigree-based genetic analysis of familial hypercholesterolemia

by Mika Hori, Atsushi Takahashi, Cheol Son, Masatsune Ogura, Mariko Harada-Shiba
Published 2020-04-01

Superior Silencing by 2′,4′-BNANC-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

by Tsuyoshi Yamamoto, Hidenori Yasuhara, Fumito Wada, Mariko Harada-Shiba, Takeshi Imanishi, Satoshi Obika
Published 2012-01-01

VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body

by Hideaki Yamamoto, Tappei Takada, Yoshihide Yamanashi, Masatsune Ogura, Yusuke Masuo, Mariko Harada-Shiba, Hiroshi Suzuki
Published 2017-04-01

Crude α-Mangostin Suppresses the Development of Atherosclerotic Lesions in <i>Apoe</i>-Deficient Mice by a Possible M2 Macrophage-Mediated Mechanism

by Masa-Aki Shibata, Mariko Harada-Shiba, Eiko Shibata, Hideki Tosa, Yoshinobu Matoba, Hitomi Hamaoka, Munekazu Iinuma, Yoichi Kondo
Published 2019-04-01

Development of a 2′,4′-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo

by Shunsuke Wada, Satoshi Obika, Masa-Aki Shibata, Tsuyoshi Yamamoto, Moeka Nakatani, Tetsuji Yamaoka, Hidetaka Torigoe, Mariko Harada-Shiba
Published 2012-01-01

Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

by Tsuyoshi Yamamoto, Yahiro Mukai, Fumito Wada, Chisato Terada, Yukina Kayaba, Kaho Oh, Asako Yamayoshi, Satoshi Obika, Mariko Harada–Shiba
Published 2021-05-01

Efficacy and safety of alirocumab in patients with hypercholesterolemia not adequately controlled with non-statin lipid-lowering therapy or the lowest strength of statin: ODYSSEY N...

by Tamio Teramoto, Akira Kondo, Arihiro Kiyosue, Mariko Harada-Shiba, Yasushi Ishigaki, Kimimasa Tobita, Yumiko Kawabata, Asuka Ozaki, Marie T. Baccara-Dinet, Masataka Sata
Published 2017-06-01

Dose-Dependent Effect of Intravenous Administration of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Neonatal Stroke Mice

by Emi Tanaka, Emi Tanaka, Yuko Ogawa, Takeo Mukai, Yoshiaki Sato, Takashi Hamazaki, Tokiko Nagamura-Inoue, Mariko Harada-Shiba, Haruo Shintaku, Masahiro Tsuji
Published 2018-03-01

Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy

by Satoshi Saito, Yumi Yamamoto, Takakuni Maki, Yorito Hattori, Hideki Ito, Katsuhiko Mizuno, Mariko Harada-Shiba, Raj N. Kalaria, Masanori Fukushima, Ryosuke Takahashi, Masafumi Ihara
Published 2017-04-01

Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

by Kiyoko Setoguchi, Lin Cui, Nobutaka Hachisuka, Sumalee Obchoei, Kentaro Shinkai, Fuminori Hyodo, Kiyoko Kato, Fumito Wada, Tsuyoshi Yamamoto, Mariko Harada-Shiba, Satoshi Obika, Kenji Nakano
Published 2017-12-01

Circulating Mature PCSK9 Level Predicts Diminished Response to Statin Therapy

by Naoto Kuyama, Yu Kataoka, Misa Takegami, Kunihiro Nishimura, Mariko Harada‐Shiba, Mika Hori, Masatsune Ogura, Fumiyuki Otsuka, Yasuhide Asaumi, Teruo Noguchi, Kenichi Tsujita, Satoshi Yasuda
Published 2021-06-01

Cholesterol-lowering Action of BNA-based Antisense Oligonucleotides Targeting PCSK9 in Atherogenic Diet-induced Hypercholesterolemic Mice

by Tsuyoshi Yamamoto, Mariko Harada-Shiba, Moeka Nakatani, Shunsuke Wada, Hidenori Yasuhara, Keisuke Narukawa, Kiyomi Sasaki, Masa-Aki Shibata, Hidetaka Torigoe, Tetsuji Yamaoka, Takeshi Imanishi, Satoshi Obika
Published 2012-01-01

Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages

by Masato Furuhashi, Masatsune Ogura, Megumi Matsumoto, Satoshi Yuda, Atsuko Muranaka, Mina Kawamukai, Akina Omori, Marenao Tanaka, Norihito Moniwa, Hirofumi Ohnishi, Shigeyuki Saitoh, Mariko Harada-Shiba, Kazuaki Shimamoto, Tetsuji Miura
Published 2017-03-01

Patients With <italic toggle="yes">LDLR</italic> and <italic toggle="yes">PCSK9</italic> Gene Variants Experienced Higher Incidence of Cardiovascular Outcomes in Heterozygous Famil...

by Takahito Doi, Mika Hori, Mariko Harada‐Shiba, Yu Kataoka, Daisuke Onozuka, Kunihiro Nishimura, Ryo Nishikawa, Kosuke Tsuda, Masatsune Ogura, Cheol Son, Yoshihiro Miyamoto, Teruo Noguchi, Hiroaki Shimokawa, Satoshi Yasuda
Published 2021-02-01

Comparison of angiogenic, cytoprotective, and immunosuppressive properties of human amnion- and chorion-derived mesenchymal stem cells.

by Kenichi Yamahara, Kazuhiko Harada, Makiko Ohshima, Shin Ishikane, Shunsuke Ohnishi, Hidetoshi Tsuda, Kentaro Otani, Akihiko Taguchi, Toshihiro Soma, Hiroyasu Ogawa, Shinji Katsuragi, Jun Yoshimatsu, Mariko Harada-Shiba, Kenji Kangawa, Tomoaki Ikeda
Published 2014-01-01

Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease

by Yumi Yamamoto, Katsutoshi Kojima, Daisuke Taura, Masakatsu Sone, Kazuo Washida, Naohiro Egawa, Takayuki Kondo, Eiko N. Minakawa, Kayoko Tsukita, Takako Enami, Hidekazu Tomimoto, Toshiki Mizuno, Raj N. Kalaria, Nobuya Inagaki, Ryosuke Takahashi, Mariko Harada-Shiba, Masafumi Ihara, Haruhisa Inoue
Published 2020-03-01

Substantially Elevated Atherosclerotic Risks in Japanese Severe Familial Hypercholesterolemia Defined by the International Atherosclerosis Society

by Sayaka Funabashi, MD, Yu Kataoka, MD, PhD, Mika Hori, PhD, Masatsune Ogura, MD, PhD, Yuriko Nakaoku, MD, PhD, Kunihiro Nishimura, MD, PhD, Takahito Doi, MD, PhD, Ryo Nishikawa, MD, Kosuke Tsuda, MD, Teruo Noguchi, MD, PhD, Mariko Harada-Shiba, MD, PhD
Published 2021-09-01