Epicardial TGFβ and BMP Signaling in Cardiac Regeneration: What Lesson Can We Learn from the Developing Heart?

by Esther Dronkers, Manon M.M. Wauters, Marie José Goumans, Anke M. Smits
Published 2020-03-01

TGF-β and BMPR2 Signaling in PAH: Two Black Sheep in One Family

by Nina Rol, Konda Babu Kurakula, Chris Happé, Harm Jan Bogaard, Marie-José Goumans
Published 2018-08-01

Thoracic Aortic Aneurysm Development in Patients with Bicuspid Aortic Valve: What Is the Role of Endothelial Cells?

by Vera van de Pol, Kondababu Kurakula, Marco C. DeRuiter, Marie-José Goumans
Published 2017-11-01

TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering

by Jin Ma, Jin Ma, Gonzalo Sanchez-Duffhues, Marie-José Goumans, Peter ten Dijke, Peter ten Dijke
Published 2020-04-01

Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva

by Francesc Ventura, Eleanor Williams, Makoto Ikeya, Alex N. Bullock, Peter ten Dijke, Marie-José Goumans, Gonzalo Sanchez-Duffhues
Published 2021-02-01

Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence?

by Kondababu Kurakula, Valérie F.E.D. Smolders, Olga Tura-Ceide, J. Wouter Jukema, Paul H. A. Quax, Marie-José Goumans
Published 2021-01-01

Altered TGFβ/SMAD Signaling in Human and Rat Models of Pulmonary Hypertension: An Old Target Needs Attention

by Takayuki Jujo Sanada, Xiao-Qing Sun, Chris Happé, Christophe Guignabert, Ly Tu, Ingrid Schalij, Harm-Jan Bogaard, Marie-José Goumans, Kondababu Kurakula
Published 2021-01-01

TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity

by Arjan van Caam, Wojciech Madej, Amaya Garcia de Vinuesa, Marie-José Goumans, Peter ten Dijke, Esmeralda Blaney Davidson, Peter van der Kraan
Published 2017-05-01

Pulmonary Arterial Hypertension and Hereditary Haemorrhagic Telangiectasia

by Veronique M. M. Vorselaars, Anna E. Hosman, Cornelis J. J. Westermann, Repke J. Snijder, Johannes J. Mager, Marie-Jose Goumans, Marco C. Post
Published 2018-10-01

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants.

by Sonja E M Boas, Joao Carvalho, Joao Carvalho, Marloes van den Broek, Ester M Weijers, Marie-José Goumans, Pieter Koolwijk, Roeland M H Merks
Published 2018-07-01

Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction.

by Calinda K E Dingenouts, Wineke Bakker, Kirsten Lodder, Karien C Wiesmeijer, Asja T Moerkamp, Janita A Maring, Helen M Arthur, Anke M Smits, Marie-José Goumans
Published 2017-01-01

Endothelial dysfunction in pulmonary arterial hypertension: loss of cilia length regulation upon cytokine stimulation

by Anneloes Dummer, Nina Rol, Robert Szulcek, Kondababu Kurakula, Xiaoke Pan, Benjamin I. Visser, Harm Jan Bogaard, Marco C. DeRuiter, Marie-José Goumans, Beerend P. Hierck
Published 2018-03-01

MnTBAP Reverses Pulmonary Vascular Remodeling and Improves Cardiac Function in Experimentally Induced Pulmonary Arterial Hypertension

by Maria Catalina Gomez-Puerto, Xiao-Qing Sun, Ingrid Schalij, Mar Orriols, Xiaoke Pan, Robert Szulcek, Marie-José Goumans, Harm-Jan Bogaard, Qian Zhou, Peter ten Dijke
Published 2020-06-01

The Inflammatory Profile of CTEPH-Derived Endothelial Cells Is a Possible Driver of Disease Progression

by Valérie F. E. D. Smolders, Kirsten Lodder, Cristina Rodríguez, Olga Tura-Ceide, Joan Albert Barberà, J. Wouter Jukema, Paul H.A. Quax, Marie José Goumans, Kondababu Kurakula
Published 2021-03-01

Part and Parcel of the Cardiac Autonomic Nerve System: Unravelling Its Cellular Building Blocks during Development

by Anna M. D. Végh, Sjoerd N. Duim, Anke M. Smits, Robert E. Poelmann, Arend D. J. ten Harkel, Marco C. DeRuiter, Marie José Goumans, Monique R. M. Jongbloed
Published 2016-09-01

Effects of 6-mercaptopurine in pressure overload induced right heart failure.

by Julie Birkmose Axelsen, Stine Andersen, Xiao-Qing Sun, Steffen Ringgaard, Janus Adler Hyldebrandt, Kondababu Kurakula, Marie-José Goumans, Frances S de Man, Jens Erik Nielsen-Kudsk, Harm-Jan Bogaard, Asger Andersen
Published 2019-01-01

Endothelial Colony Forming Cells as an Autologous Model to Study Endothelial Dysfunction in Patients with a Bicuspid Aortic Valve

by Vera van de Pol, Lidia R. Bons, Kirsten Lodder, Konda Babu Kurakula, Gonzalo Sanchez-Duffhues, Hans-Marc J. Siebelink, Jolien W. Roos-Hesselink, Marco C. DeRuiter, Marie-José Goumans
Published 2019-07-01

Cripto favours chondrocyte hypertrophy via TGF-beta SMAD1/5 signaling in experimental osteoarthritis

by Gonzalo Sanchez-Duffhues, Amaya Garcia de Vinuesa Antuñano, Esmeralda Blaney-Davidson, Arjan van Caam, Kirsten Lodder, Yolande Ramos, Margreet Kloppenburg, Ingrid Meulenbelt, Peter van der Kraan, Marie-José Goumans, Peter ten Dijke
Published 2021-04-01

Extracellular Matrix Analysis of Human Renal Arteries in Both Quiescent and Active Vascular State

by Christian G.M. van Dijk, Laura Louzao-Martinez, Elise van Mulligen, Bart Boermans, Jeroen A.A. Demmers, Thierry P.P. van den Bosch, Marie-José Goumans, Dirk J. Duncker, Marianne C. Verhaar, Caroline Cheng
Published 2020-05-01

In vivo and in vitro Approaches Reveal Novel Insight Into the Ability of Epicardium-Derived Cells to Create Their Own Extracellular Environment

by Noortje A. M. Bax, Noortje A. M. Bax, Noortje A. M. Bax, Sjoerd N. Duim, Sjoerd N. Duim, Boudewijn P. T. Kruithof, Anke M. Smits, Carlijn V. C. Bouten, Carlijn V. C. Bouten, Marie José Goumans
Published 2019-06-01