The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins.

by Ryan Higgins, Marie-Helene Kabbaj, Alexa Hatcher, Yanchang Wang
Published 2018-01-01

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.

by Michael Bokros, Delaney Sherwin, Marie-Helene Kabbaj, Yanchang Wang
Published 2021-05-01

The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis

by Ryan Higgins, Marie-Helene Kabbaj, Delaney Sherwin, Lauren A. Howell, Alexa Hatcher, Robert J. Tomko, Jr., Yanchang Wang
Published 2020-07-01