The enteropathogenic E. coli (EPEC) Tir effector inhibits NF-κB activity by targeting TNFα receptor-associated factors.

by Marie-Hélène Ruchaud-Sparagano, Sabrina Mühlen, Paul Dean, Brendan Kenny
Published 2011-12-01

Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury

by James G. Macfarlane, David A. Dorward, Marie-Hélène Ruchaud-Sparagano, Jonathan Scott, Christopher D. Lucas, Adriano G. Rossi, A. John Simpson
Published 2020-10-01

Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace

by Laura Jardine, Sarah Wiscombe, Gary Reynolds, David McDonald, Andrew Fuller, Kile Green, Andrew Filby, Ian Forrest, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Matthew Collin, Muzlifah Haniffa, A. John Simpson
Published 2019-04-01

Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses

by John D. Widdrington, John D. Widdrington, Aurora Gomez-Duran, Aurora Gomez-Duran, Aurora Gomez-Duran, Angela Pyle, Marie-Helene Ruchaud-Sparagano, Jonathan Scott, Simon V. Baudouin, Anthony J. Rostron, Penny E. Lovat, Patrick F. Chinnery, Patrick F. Chinnery, Patrick F. Chinnery, A. John Simpson
Published 2018-09-01