iVS analysis to evaluate the impact of scaffold diversity in the binding to cellular targets relevant in cancer

by Agostino Cilibrizzi, Giuseppe Floresta, Vincenzo Abbate, Maria Paola Giovannoni
Published 2019-01-01

Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening

by Giuseppe Floresta, Letizia Crocetti, Maria Paola Giovannoni, Pierfrancesco Biagini, Agostino Cilibrizzi
Published 2020-01-01

Synthesis of New GABA_A Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold

by Gabriella Guerrini, Claudia Vergelli, Niccolò Cantini, Maria Paola Giovannoni, Simona Daniele, Maria Paola Mascia, Claudia Martini, Letizia Crocetti
Published 2019-03-01

Novel Sulfonamide Analogs of Sivelestat as Potent Human Neutrophil Elastase Inhibitors

by Letizia Crocetti, Maria Paola Giovannoni, Niccolò Cantini, Gabriella Guerrini, Claudia Vergelli, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn
Published 2020-09-01

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

by Claudia Vergelli, Igor A. Schepetkin, Letizia Crocetti, Antonella Iacovone, Maria Paola Giovannoni, Gabriella Guerrini, Andrei I. Khlebnikov, Samuele Ciattini, Giovanna Ciciani, Mark T. Quinn
Published 2017-01-01

Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors

by Letizia Crocetti, Gianluca Bartolucci, Agostino Cilibrizzi, Maria Paola Giovannoni, Gabriella Guerrini, Antonella Iacovone, Marta Menicatti, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn, Claudia Vergelli
Published 2017-12-01

Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors

by Maria Paola Giovannoni, Igor A. Schepetkin, Mark T. Quinn, Niccolò Cantini, Letizia Crocetti, Gabriella Guerrini, Antonella Iacovone, Paola Paoli, Patrizia Rossi, Gianluca Bartolucci, Marta Menicatti, Claudia Vergelli
Published 2018-01-01