Insights into the N-sulfation mechanism: molecular dynamics simulations of the N-sulfotransferase domain of NDST1 and mutants.

by Tarsis F Gesteira, Laércio Pol-Fachin, Vivien Jane Coulson-Thomas, Marcelo A Lima, Hugo Verli, Helena B Nader
Published 2013-01-01

Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants

by Aline Mendes, Maria C. Z. Meneghetti, Marcelly Valle Palladino, Giselle Zenker Justo, Guilherme L. Sassaki, Jawed Fareed, Marcelo A. Lima, Helena B. Nader
Published 2019-08-01

A Glycosaminoglycan Extract from <i>Portunus pelagicus</i> Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease

by Courtney J. Mycroft-West, Lynsay C. Cooper, Anthony J. Devlin, Patricia Procter, Scott E. Guimond, Marco Guerrini, David G. Fernig, Marcelo A. Lima, Edwin A. Yates, Mark A. Skidmore
Published 2019-05-01

Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate extract from Sardina pilchardus

by Courtney J Mycroft-West, Anthony J Devlin, Lynsay C Cooper, Patricia Procter, Gavin J Miller, David G Fernig, Marco Guerrini, Scott E Guimond, Marcelo A Lima, Edwin A Yates, Mark Andrew Skidmore
Published 2020-01-01

Glycosaminoglycans from <i>Litopenaeus vannamei</i> Inhibit the Alzheimer’s Disease β Secretase, BACE1

by Courtney J. Mycroft-West, Anthony J. Devlin, Lynsay C. Cooper, Scott E. Guimond, Patricia Procter, Marco Guerrini, Gavin J. Miller, David G. Fernig, Edwin A. Yates, Marcelo A. Lima, Mark A. Skidmore
Published 2021-04-01

Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger

by Carlos M. G. de Godoy, Ênio R. Vasques, Ênio R. Vasques, Afonso Caricati-Neto, José G. P. Tavares, Beatriz J. Alves, Juliana Duarte, Regiane Miranda-Ferreira, Marcelo A. Lima, Helena B. Nader, Ivarne L. dos Santos Tersariol, Ivarne L. dos Santos Tersariol
Published 2018-06-01

Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain

by Zachariah P. Schuurs, Edward Hammond, Stefano Elli, Timothy R. Rudd, Courtney J. Mycroft-West, Marcelo A. Lima, Mark A. Skidmore, Richard Karlsson, Yen-Hsi Chen, Ieva Bagdonaite, Zhang Yang, Yassir A. Ahmed, Derek J. Richard, Jeremy Turnbull, Vito Ferro, Deirdre R. Coombe, Neha S. Gandhi
Published 2021-01-01

A new approach for heparin standardization: combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis.

by Marcelo A Lima, Timothy R Rudd, Eduardo H C de Farias, Lyvia F Ebner, Tarsis F Gesteira, Lauro M de Souza, Aline Mendes, Carolina R Córdula, João R M Martins, Debra Hoppensteadt, Jawed Fareed, Guilherme L Sassaki, Edwin A Yates, Ivarne L S Tersariol, Helena B Nader
Published 2011-01-01