DNA, RNA, and Protein Tools for Editing the Genetic Information in Human Cells

by Xiaoyu Chen, Manuel A.F.V. Gonçalves
Published 2018-08-01

Adenoviral Vectors Meet Gene Editing: A Rising Partnership for the Genomic Engineering of Human Stem Cells and Their Progeny

by Francesca Tasca, Qian Wang, Manuel A.F.V. Gonçalves
Published 2020-04-01

Novel Therapeutic Approaches for the Treatment of Retinal Degenerative Diseases: Focus on CRISPR/Cas-Based Gene Editing

by Carmen Gallego, Manuel A. F. V. Gonçalves, Jan Wijnholds, Jan Wijnholds
Published 2020-08-01

High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of <i>DMD</i> Gene Repair Tools and Strategies in Human Cells

by Marcella Brescia, Josephine M. Janssen, Jin Liu, Manuel A. F. V. Gonçalves
Published 2020-04-01

The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events

by Josephine M. Janssen, Xiaoyu Chen, Jin Liu, Manuel A.F.V. Gonçalves
Published 2019-06-01

The Chromatin Structure Differentially Impacts High-Specificity CRISPR-Cas9 Nuclease Strategies

by Xiaoyu Chen, Jin Liu, Josephine M. Janssen, Manuel A.F.V. Gonçalves
Published 2017-09-01

Rapid and sensitive lentivirus vector-based conditional gene expression assay to monitor and quantify cell fusion activity.

by Manuel A F V Gonçalves, Josephine M Janssen, Maarten Holkers, Antoine A F de Vries
Published 2010-06-01

Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system.

by Manuel A F V Gonçalves, Maarten Holkers, Gijsbert P van Nierop, Roeland Wieringa, Maria G Pau, Antoine A F de Vries
Published 2008-08-01

In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting

by Xiaoyu Chen, Josephine M. Janssen, Jin Liu, Ignazio Maggio, Anke E. J. ‘t Jong, Harald M.M. Mikkers, Manuel A. F. V. Gonçalves
Published 2017-09-01

A Small Key for a Heavy Door: Genetic Therapies for the Treatment of Hemoglobinopathies

by Hidde A. Zittersteijn, Cornelis L. Harteveld, Stefanie Klaver-Flores, Arjan C. Lankester, Rob C. Hoeben, Frank J. T. Staal, Manuel A. F. V. Gonçalves
Published 2021-02-01

Genomic Engineering in Human Hematopoietic Stem Cells: Hype or Hope?

by Stefanie Klaver-Flores, Hidde A. Zittersteijn, Kirsten Canté-Barrett, Arjan Lankester, Rob C. Hoeben, Manuel A. F. V. Gonçalves, Karin Pike-Overzet, Frank J. T. Staal
Published 2021-01-01

Long-Term Contribution of Human Bone Marrow Mesenchymal Stromal Cells to Skeletal Muscle Regeneration in Mice

by Anabel S. De La Garza-Rodea, Ietje Van Der Velde, Hester Boersma, Manuel A. F. V. Gonçalves, Dirk W. Van Bekkum, Antoine A. F. De Vries, Shoshan Knaän-Shanzer Ph.D.
Published 2011-03-01

Myogenic Properties of Human Mesenchymal Stem Cells Derived from Three Different Sources

by Anabel S. De La Garza-Rodea, Ietje Van Der Velde-Van Dijke, Hester Boersma, Manuel A. F. V. Gonçalves, Dirk W. Van Bekkum, Antoine A. F. De Vries, Shoshan Knaän-Shanzer Ph.D.
Published 2012-02-01

TGF-β-Induced Endothelial to Mesenchymal Transition Is Determined by a Balance Between SNAIL and ID Factors

by Jin Ma, Jin Ma, Gerard van der Zon, Gerard van der Zon, Manuel A. F. V. Gonçalves, Maarten van Dinther, Maarten van Dinther, Midory Thorikay, Midory Thorikay, Gonzalo Sanchez-Duffhues, Peter ten Dijke, Peter ten Dijke
Published 2021-02-01