Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

by Lukas Villiger, Lukas Schmidheini, Nicolas Mathis, Tanja Rothgangl, Kim Marquart, Gerald Schwank
Published 2021-12-01

Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens

by Kim F. Marquart, Ahmed Allam, Sharan Janjuha, Anna Sintsova, Lukas Villiger, Nina Frey, Michael Krauthammer, Gerald Schwank
Published 2021-08-01

Neurodegeneration and unfolded-protein response in mice expressing a membrane-tethered flexible tail of PrP.

by Paolo Dametto, Asvin K K Lakkaraju, Claire Bridel, Lukas Villiger, Tracy O'Connor, Uli S Herrmann, Pawel Pelczar, Thomas Rülicke, Donal McHugh, Arlind Adili, Adriano Aguzzi
Published 2015-01-01