Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a 1H-NMR Method to Assess Deacetylase Activity

by Nicholas J. Westwood, Sonia Lain, Tomas Lebl, Daumantas Matulis, Asta Zubrienė, Anna R. McCarthy, Louise L. Major, Vaida Morkūnaitė, Lisa Pirrie
Published 2012-10-01

Novel Benzothiazole-Based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer’s Disease Treatment

by Laura Aitken, Ondrej Benek, Brogan E. McKelvie, Rebecca E. Hughes, Lukas Hroch, Monika Schmidt, Louise L. Major, Lucie Vinklarova, Kamil Kuca, Terry K. Smith, Kamil Musilek, Frank J. Gunn-Moore
Published 2019-07-01

Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

by Luís Gaspar, Ross P Coron, Paul KongThoo Lin, David M Costa, Begoña Perez-Cabezas, Joana Tavares, Meritxell Roura-Ferrer, Isbaal Ramos, Céline Ronin, Louise L Major, Fabrice Ciesielski, Iain K Pemberton, Jane MacDougall, Paola Ciapetti, Terry K Smith, Anabela Cordeiro-da-Silva
Published 2018-01-01