Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.

by Kathy Triantafilou, Christopher J K Ward, Magdalena Czubala, Robert G Ferris, Emma Koppe, Curt Haffner, Vincent Piguet, Vipulkumar K Patel, Heather Amrine-Madsen, Louise K Modis, Seth L Masters, Martha Triantafilou
Published 2021-04-01

The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat.

by Ryan M Fryer, Akalushi Muthukumarana, Paul C Harrison, Suzanne Nodop Mazurek, Rong Rhonda Chen, Kyle E Harrington, Roger M Dinallo, Joshua C Horan, Lori Patnaude, Louise K Modis, Glenn A Reinhart
Published 2012-01-01

Malonylation of GAPDH is an inflammatory signal in macrophages

by Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill
Published 2019-01-01

A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.

by Nuruddeen D Lewis, Lori A Patnaude, Josephine Pelletier, Donald J Souza, Susan M Lukas, F James King, Jonathan D Hill, Dimitria E Stefanopoulos, Kelli Ryan, Sudha Desai, Donna Skow, Stefan G Kauschke, Andre Broermann, Daniel Kuzmich, Christian Harcken, Eugene R Hickey, Louise K Modis
Published 2014-01-01

CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells.

by Nuruddeen D Lewis, Akalushi Muthukumarana, Steven E Fogal, Laura Corradini, Dimitria E Stefanopoulos, Prathima Adusumalli, Josephine Pelletier, Mark Panzenbeck, Karen Berg, Melissa Canfield, Brian N Cook, Hossein Razavi, Daniel Kuzmich, Shawn Anderson, Devan Allard, Paul Harrison, Christine Grimaldi, Donald Souza, Christian Harcken, Ryan M Fryer, Louise K Modis, Maryanne L Brown
Published 2014-01-01