The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila.

by Jenna M Gregory, Teresa P Barros, Sarah Meehan, Christopher M Dobson, Leila M Luheshi
Published 2012-01-01

Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils.

by Mookyung Cheon, Iksoo Chang, Sandipan Mohanty, Leila M Luheshi, Christopher M Dobson, Michele Vendruscolo, Giorgio Favrin
Published 2007-09-01

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.

by Leila M Luheshi, Gian Gaetano Tartaglia, Ann-Christin Brorsson, Amol P Pawar, Ian E Watson, Fabrizio Chiti, Michele Vendruscolo, David A Lomas, Christopher M Dobson, Damian C Crowther
Published 2007-10-01

Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.

by Leila M Luheshi, Wolfgang Hoyer, Teresa Pereira de Barros, Iris van Dijk Härd, Ann-Christin Brorsson, Bertil Macao, Cecilia Persson, Damian C Crowther, David A Lomas, Stefan Ståhl, Christopher M Dobson, Torleif Härd
Published 2010-03-01

Clusterin protects neurons against intracellular proteotoxicity

by Jenna M. Gregory, Daniel R. Whiten, Rebecca A. Brown, Teresa P. Barros, Janet R. Kumita, Justin J. Yerbury, Sandeep Satapathy, Karina McDade, Colin Smith, Leila M. Luheshi, Christopher M. Dobson, Mark R. Wilson
Published 2017-11-01