HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients

by Zhaobo Li, Lihong Zhou, Chrisostomos Prodromou, Velibor Savic, Laurence H. Pearl
Published 2017-06-01

BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

by Matthew Day, Mathieu Rappas, Katie Ptasinska, Dominik Boos, Antony W Oliver, Laurence H Pearl
Published 2018-10-01

The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90.

by Katie L I M Blundell, Mohinder Pal, S Mark Roe, Laurence H Pearl, Chrisostomos Prodromou
Published 2017-01-01

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

by Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver, Laurence H Pearl
Published 2019-05-01

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

by Gabrielle J. Grundy, Stuart L. Rulten, Raquel Arribas-Bosacoma, Kathryn Davidson, Zuzanna Kozik, Antony W. Oliver, Laurence H. Pearl, Keith W. Caldecott
Published 2016-04-01

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX

by Robert A. Baldock, Matthew Day, Oliver J. Wilkinson, Ross Cloney, Penelope A. Jeggo, Antony W. Oliver, Felicity Z. Watts, Laurence H. Pearl
Published 2015-12-01

A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus.

by Nicholas E Peters, Brian J Ferguson, Michela Mazzon, Aodhnait S Fahy, Ewelina Krysztofinska, Raquel Arribas-Bosacoma, Laurence H Pearl, Hongwei Ren, Geoffrey L Smith
Published 2013-01-01

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

by Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
Published 2018-04-01

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

by Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
Published 2018-07-01

Specialized interfaces of Smc5/6 control hinge stability and DNA association

by Aaron Alt, Hung Q. Dang, Owen S. Wells, Luis M. Polo, Matt A. Smith, Grant A. McGregor, Thomas Welte, Alan R. Lehmann, Laurence H. Pearl, Johanne M. Murray, Antony W. Oliver
Published 2017-01-01

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

by Stephen T. Hallett, Martyna W. Pastok, R. Marc L. Morgan, Anita Wittner, Katie L.I.M. Blundell, Ildiko Felletar, Stephen R. Wedge, Chrisostomos Prodromou, Martin E.M. Noble, Laurence H. Pearl, Jane A. Endicott
Published 2017-10-01

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

by Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott
Published 2016-08-01

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

by Xiangrong Chen, Yusuf I Ali, Charlotte EL Fisher, Raquel Arribas-Bosacoma, Mohan B Rajasekaran, Gareth Williams, Sarah Walker, Jessica R Booth, Jessica JR Hudson, S Mark Roe, Laurence H Pearl, Simon E Ward, Frances MG Pearl, Antony W Oliver
Published 2021-03-01