Inhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia.

by Kari Högstrand, Eduar Hejll, Birgitta Sander, Björn Rozell, Lars-Gunnar Larsson, Alf Grandien
Published 2012-01-01

PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

by Andrä Brunner, Aldwin Suryo Rahmanto, Henrik Johansson, Marcela Franco, Johanna Viiliäinen, Mohiuddin Gazi, Oliver Frings, Erik Fredlund, Charles Spruck, Janne Lehtiö, Juha K Rantala, Lars-Gunnar Larsson, Olle Sangfelt
Published 2020-07-01

Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage.

by Lina Guerra, Ami Albihn, Susanna Tronnersjö, Qinzi Yan, Riccardo Guidi, Bo Stenerlöw, Torsten Sterzenbach, Christine Josenhans, James G Fox, David B Schauer, Monica Thelestam, Lars-Gunnar Larsson, Marie Henriksson, Teresa Frisan
Published 2010-01-01