Streptococcal Enzymes as Precision Tools Against Pathogenic IgG Autoantibodies in Small Vessel Vasculitis

by Mårten Segelmark, Lars Björck
Published 2019-09-01

Finegoldia magna, an Anaerobic Gram-Positive Bacterium of the Normal Human Microbiota, Induces Inflammation by Activating Neutrophils

by Ariane Neumann, Lars Björck, Inga-Maria Frick
Published 2020-01-01

IdeS: a bacterial proteolytic enzyme with therapeutic potential.

by Björn P Johansson, Oonagh Shannon, Lars Björck
Published 2008-01-01

Streptococcal protein SIC activates monocytes and induces inflammation

by Ariane Neumann, Lotta Happonen, Christofer Karlsson, Wael Bahnan, Inga-Maria Frick, Lars Björck
Published 2021-04-01

Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response.

by Fredrik Kahn, Matthias Mörgelin, Oonagh Shannon, Anna Norrby-Teglund, Heiko Herwald, Anders I Olin, Lars Björck
Published 2008-01-01

The Molecular Basis of Human IgG-Mediated Enhancement of C4b-Binding Protein Recruitment to Group A Streptococcus

by David Ermert, David Ermert, Maisem Laabei, Antonin Weckel, Matthias Mörgelin, Martin Lundqvist, Lars Björck, Sanjay Ram, Sara Linse, Anna M. Blom
Published 2019-06-01

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production

by Johannes Westman, Bhavya Chakrakodi, Johanna Snäll, Matthias Mörgelin, Martin Bruun Madsen, Ole Hyldegaard, Ariane Neumann, Inga-Maria Frick, Anna Norrby-Teglund, Lars Björck, Heiko Herwald
Published 2018-02-01

A quantitative Streptococcus pyogenes–human protein–protein interaction map reveals localization of opsonizing antibodies

by Lotta Happonen, Simon Hauri, Gabriel Svensson Birkedal, Christofer Karlsson, Therese de Neergaard, Hamed Khakzad, Pontus Nordenfelt, Mats Wikström, Magdalena Wisniewska, Lars Björck, Lars Malmström, Johan Malmström
Published 2019-06-01

Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS--A Novel Therapeutic Opportunity.

by Lena Winstedt, Sofia Järnum, Emma Andersson Nordahl, Andreas Olsson, Anna Runström, Robert Bockermann, Christofer Karlsson, Johan Malmström, Gabriella Samuelsson Palmgren, Ulf Malmqvist, Lars Björck, Christian Kjellman
Published 2015-01-01

Vaccine-induced, but not natural immunity, against the Streptococcal inhibitor of complement protects against invasive disease

by Lionel K. K. Tan, Mark Reglinski, Daryl Teo, Nada Reza, Lucy E. M. Lamb, Vaitehi Nageshwaran, Claire E. Turner, Mats Wikstrom, Inga-Maria Frick, Lars Bjorck, Shiranee Sriskandan
Published 2021-04-01