Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics

by Lisa M. Stanek, Jie Bu, Lamya S. Shihabuddin
Published 2019-09-01

Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis

by James C. Dodge, Jinlong Yu, S. Pablo Sardi, Lamya S. Shihabuddin
Published 2021-01-01

Viral delivery of a microRNA to Gba to the mouse central nervous system models neuronopathic Gaucher disease

by Kasey L. Jackson, Catherine Viel, Jennifer Clarke, Jie Bu, Monyrath Chan, Bing Wang, Lamya S. Shihabuddin, S. Pablo Sardi
Published 2019-10-01

Comparative analysis of acid sphingomyelinase distribution in the CNS of rats and mice following intracerebroventricular delivery.

by Christopher M Treleaven, Thomas Tamsett, Jonathan A Fidler, Tatyana V Taksir, Seng H Cheng, Lamya S Shihabuddin, James C Dodge
Published 2011-01-01

Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease

by Piotr Hadaczek, Lisa Stanek, Agnieszka Ciesielska, Vivek Sudhakar, Lluis Samaranch, Philip Pivirotto, John Bringas, Catherine O'Riordan, Bryan Mastis, Waldy San Sebastian, John Forsayeth, Seng H Cheng, Krystof S Bankiewicz, Lamya S Shihabuddin
Published 2016-01-01

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

by Bibiana K.Y. Wong, Dagmar E. Ehrnhoefer, Rona K. Graham, Dale D.O. Martin, Safia Ladha, Valeria Uribe, Lisa M. Stanek, Sonia Franciosi, Xiaofan Qiu, Yu Deng, Vlad Kovalik, Weining Zhang, Mahmoud A. Pouladi, Lamya S. Shihabuddin, Michael R. Hayden
Published 2015-04-01