The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies

by Selma P. Wiertsema, Jeroen van Bergenhenegouwen, Johan Garssen, Leon M. J. Knippels
Published 2021-03-01

Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy

by Xiaoli Zhao, Suzan Thijssen, Hongbing Chen, Johan Garssen, Leon M. J. Knippels, Astrid Hogenkamp
Published 2021-07-01

In Vitro Evidence for Immune-Modulatory Properties of Non-Digestible Oligosaccharides: Direct Effect on Human Monocyte Derived Dendritic Cells.

by Sarah Lehmann, Julia Hiller, Jeroen van Bergenhenegouwen, Leon M J Knippels, Johan Garssen, Claudia Traidl-Hoffmann
Published 2015-01-01

Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow’s Milk Allergy Model: A Potential Role for Foxp3+ Regulatory T Cells

by Marlotte M. Vonk, Marlotte M. Vonk, Mara A. P. Diks, Laura Wagenaar, Joost J. Smit, Raymond H. H. Pieters, Johan Garssen, Johan Garssen, Betty C. A. M. van Esch, Betty C. A. M. van Esch, Léon M. J. Knippels, Léon M. J. Knippels
Published 2017-09-01

Dietary Intervention with β-Lactoglobulin-Derived Peptides and a Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates the Prevention of Whey-Indu...

by Atanaska I. Kostadinova, Atanaska I. Kostadinova, Alba Pablos-Tanarro, Alba Pablos-Tanarro, Mara A. P. Diks, Betty C. A. M. van Esch, Betty C. A. M. van Esch, Johan Garssen, Johan Garssen, Léon M. J. Knippels, Léon M. J. Knippels, Linette E. M. Willemsen
Published 2017-10-01

Seeking Windows of Opportunity to Shape Lifelong Immune Health: A Network-Based Strategy to Predict and Prioritize Markers of Early Life Immune Modulation

by Jolanda H. M. van Bilsen, Remon Dulos, Mariël F. van Stee, Marie Y. Meima, Tanja Rouhani Rankouhi, Lotte Neergaard Jacobsen, Anne Staudt Kvistgaard, Jossie A. Garthoff, Léon M. J. Knippels, Léon M. J. Knippels, Karen Knipping, Karen Knipping, Geert F. Houben, Lars Verschuren, Marjolein Meijerink, Shaji Krishnan
Published 2020-04-01

Development of β-lactoglobulin-specific chimeric human IgEκ monoclonal antibodies for in vitro safety assessment of whey hydrolysates.

by Karen Knipping, Peter J Simons, Laura S Buelens-Sleumer, Linda Cox, Marcel den Hartog, Niels de Jong, Reiko Teshima, Johan Garssen, Louis Boon, Léon M J Knippels
Published 2014-01-01

Ligand binding and signaling of dendritic cell immunoreceptor (DCIR) is modulated by the glycosylation of the carbohydrate recognition domain.

by Karien Bloem, Ilona M Vuist, Arend-Jan van der Plas, Léon M J Knippels, Johan Garssen, Juan J García-Vallejo, Sandra J van Vliet, Yvette van Kooyk
Published 2013-01-01

Limited Lactosylation of Beta-Lactoglobulin from Cow’s Milk Exerts Strong Influence on Antigenicity and Degranulation of Mast Cells

by Gerlof P. Bosman, Sergio Oliveira, Peter J. Simons, Javier Sastre Torano, Govert W. Somsen, Leon M. J. Knippels, Rob Haselberg, Roland J. Pieters, Johan Garssen, Karen Knipping
Published 2021-06-01

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow’s milk- and peanut allergy models

by Marlotte M. Vonk, Laura Wagenaar, Raymond H. H. Pieters, Leon M. J. Knippels, Linette E. M. Willemsen, Joost J. Smit, Betty C. A. M. van Esch, Johan Garssen
Published 2017-09-01

Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow’s Milk Allergic Mice

by Marlotte M. Vonk, Bart R. J. Blokhuis, Mara A. P. Diks, Laura Wagenaar, Joost J. Smit, Raymond H. H. Pieters, Johan Garssen, Léon M. J. Knippels, Betty C. A. M. van Esch
Published 2019-01-01

Non-digestible oligosaccharides scFOS/lcFOS facilitate safe subcutaneous immunotherapy for peanut allergy

by Laura Wagenaar, Manon van Roest, Laura J. W. Kruijssen, Peter J. Simons, Louis Boon, Marlotte M. Vonk, Betty C. A. M. van Esch, Leon M. J. Knippels, Johan Garssen, Raymond H. H. Pieters, Joost J. Smit
Published 2019-04-01

A network-based approach for identifying suitable biomarkers for oral immunotherapy of food allergy

by Jolanda H. M. van Bilsen, Lars Verschuren, Laura Wagenaar, Marlotte M. Vonk, Betty C. A. M. van Esch, Léon M. J. Knippels, Johan Garssen, Joost J. Smit, Raymond H. H. Pieters, Tim J. van den Broek
Published 2019-04-01

Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy

by Bilal Alashkar Alhamwe, Laura A.P.M. Meulenbroek, Désirée H. Veening-Griffioen, Tjalling M.D. Wehkamp, Fahd Alhamdan, Sarah Miethe, Hani Harb, Astrid Hogenkamp, Léon M.J. Knippels, Elke Pogge von Strandmann, Harald Renz, Johan Garssen, Betty C.A.M. van Esch, Holger Garn, Daniel P. Potaczek, Machteld M. Tiemessen
Published 2020-10-01

Exploring Immune Development in Infants With Moderate to Severe Atopic Dermatitis

by Lies Hulshof, Saskia A. Overbeek, Saskia A. Overbeek, Anne L. Wyllie, Mei Ling J. N. Chu, Debby Bogaert, Wilco de Jager, Leon M. J. Knippels, Leon M. J. Knippels, Elisabeth A. M. Sanders, Wim M. C. van Aalderen, Johan Garssen, Johan Garssen, Belinda van’t Land, Belinda van’t Land, Aline B. Sprikkelman, Aline B. Sprikkelman, The Clinical Study Group, A. Blauw, B. Dontje, Y. C. M. Duijvestein, W. H. C. de Boom, I. Groot, M. Boks, Y. van Kooyk, D. H. H. Fandri, D. Hijnen, M. A. Middelkamp-Hup, B. Papi, M. Roelofs, A. Rijnierse, D. Veening, Clinical Trial Support, B. J. Prakken, G. W. Ten Tusscher, R. A. Tupker, L. E. M. Willemsen
Published 2018-03-01