Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain.

by Graham M West, Francis S Willard, Kyle W Sloop, Aaron D Showalter, Bruce D Pascal, Patrick R Griffin
Published 2014-01-01

Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice

by Marlena M. Holter, Margot K. Chirikjian, Adriano Maida, Daniel A. Briere, Kyle W. Sloop, Kristina Schoonjans, Bethany P. Cummings
Published 2020-07-01

Correction: A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor.

by Lucy S Jun, Aaron D Showalter, Nosher Ali, Feihan Dai, Wenzhen Ma, Tamer Coskun, James V Ficorilli, Michael B Wheeler, M Dodson Michael, Kyle W Sloop
Published 2015-01-01

A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor.

by Lucy S Jun, Aaron D Showalter, Nosher Ali, Feihan Dai, Wenzhen Ma, Tamer Coskun, James V Ficorilli, Michael B Wheeler, M Dodson Michael, Kyle W Sloop
Published 2014-01-01

β Cell GLP-1R Signaling Alters α Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice

by Darline Garibay, Jon Lou, Seon A. Lee, Karolina E. Zaborska, Margot H. Weissman, Erica Sloma, Leanne Donahue, Andrew D. Miller, Andrew C. White, M. Dodson Michael, Kyle W. Sloop, Bethany P. Cummings
Published 2018-04-01

GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells

by Mridusmita Saikia, Marlena M. Holter, Leanne R. Donahue, Isaac S. Lee, Qiaonan C. Zheng, Journey L. Wise, Jenna E. Todero, Daryl J. Phuong, Darline Garibay, Reilly Coch, Kyle W. Sloop, Adolfo Garcia-Ocana, Charles G. Danko, Bethany P. Cummings
Published 2021-02-01

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

by Tamer Coskun, Kyle W. Sloop, Corina Loghin, Jorge Alsina-Fernandez, Shweta Urva, Krister B. Bokvist, Xuewei Cui, Daniel A. Briere, Over Cabrera, William C. Roell, Uma Kuchibhotla, Julie S. Moyers, Charles T. Benson, Ruth E. Gimeno, David A. D'Alessio, Axel Haupt
Published 2018-12-01

CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis

by Kacey J. Prentice, Stacy G. Wendell, Ying Liu, Judith A. Eversley, Sonia R. Salvatore, Haneesha Mohan, Sydney L. Brandt, Andrew C. Adams, X. Serena Wang, David Wei, Garret A. FitzGerald, Timothy B. Durham, Craig D. Hammond, Kyle W. Sloop, Carsten Skarke, Francisco J. Schopfer, Michael B. Wheeler
Published 2018-01-01

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

by Francis S. Willard, Jonathan D. Douros, Maria B.N. Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, Wijnand J.C. van der Velden, Cynthia Stutsman, Guemalli R. Cardona, Shweta Urva, Paul J. Emmerson, Jens J. Holst, David A. D’Alessio, Matthew P. Coghlan, Mette M. Rosenkilde, Jonathan E. Campbell, Kyle W. Sloop
Published 2020-09-01