Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System

by Kurt F. Hauser, Kurt F. Hauser, Kurt F. Hauser, Pamela E. Knapp, Pamela E. Knapp, Pamela E. Knapp
Published 2018-01-01

Morphine enhances HIV-1SF162-mediated neuron death and delays recovery of injured neurites.

by Ruturaj R Masvekar, Nazira El-Hage, Kurt F Hauser, Pamela E Knapp
Published 2014-01-01

HIV and opiates dysregulate K+- Cl− cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice

by Aaron J. Barbour, Kurt F. Hauser, A. Rory McQuiston, Pamela E. Knapp
Published 2020-07-01

Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice

by Aaron J. Barbour, Sara R. Nass, Yun K. Hahn, Kurt F. Hauser, Pamela E. Knapp
Published 2021-08-01

Cross-talk between microglia and neurons regulates HIV latency.

by David Alvarez-Carbonell, Fengchun Ye, Nirmala Ramanath, Yoelvis Garcia-Mesa, Pamela E Knapp, Kurt F Hauser, Jonathan Karn
Published 2019-12-01

Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription.

by Nazira El-Hage, Annadora J Bruce-Keller, Tatiana Yakovleva, Igor Bazov, Georgy Bakalkin, Pamela E Knapp, Kurt F Hauser
Published 2008-01-01

Target-Derived Matricryptins Organize Cerebellar Synapse Formation through α3β1 Integrins

by Jianmin Su, Renee S. Stenbjorn, Karen Gorse, Kaiwen Su, Kurt F. Hauser, Sylvie Ricard-Blum, Taina Pihlajaniemi, Michael A. Fox
Published 2012-08-01

A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates

by Sarah Kim, Yun Kyung Hahn, Elizabeth M Podhaizer, Virginia D McLane, Shiping Zou, Kurt F Hauser, Pamela E Knapp
Published 2018-10-01

Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered mu-opioid receptor-mediated G-protein activation and β-arrestin 2 ac...

by Yun K. Hahn, Jason J. Paris, Aron H. Lichtman, Kurt F. Hauser, Laura J. Sim-Selley, Dana E. Selley, Pamela E. Knapp
Published 2016-08-01

Chronic HIV-1 Tat exposure alters anterior cingulate cortico-basal ganglia-thalamocortical synaptic circuitry, associated behavioral control, and immune regulation in male mice

by Sara R. Nass, Yun K. Hahn, Virginia D. McLane, Neil B. Varshneya, M. Imad Damaj, Pamela E. Knapp, Kurt F. Hauser
Published 2020-05-01

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging

by Alex M. Dickens, Seung Wan Yoo, Alfred C. Chin, Jiadi Xu, Tory P. Johnson, Amanda L. Trout, Kurt F. Hauser, Norman J. Haughey
Published 2017-08-01

Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated...

by Rachel Wodarski, Deniz Bagdas, Jason J. Paris, Tim Pheby, Wisam Toma, Ruqiang Xu, M. Imad Damaj, Pamela E. Knapp, Andrew S.C. Rice, Kurt F. Hauser
Published 2018-06-01

Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects

by Jason J. Paris, Philippe Liere, Sarah Kim, Fakhri Mahdi, Meagan E. Buchanan, Sara R. Nass, Alaa N. Qrareya, Mohammed F. Salahuddin, Antoine Pianos, Neïké Fernandez, Zia Shariat-Madar, Pamela E. Knapp, Michael Schumacher, Kurt F. Hauser
Published 2020-05-01

Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: Protection by diosgenin and l-deprenyl

by Jadwiga Turchan-Cholewo, Yiling Liu, Suzanne Gartner, Rollie Reid, Chunfa Jie, Xuejun Peng, Kuey Chu C. Chen, Ashok Chauhan, Norman Haughey, Roy Cutler, Mark P. Mattson, Carlos Pardo, Katherine Conant, Ned Sacktor, Justin C. McArthur, Kurt F. Hauser, Chandra Gairola, Avindra Nath
Published 2006-07-01

Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotec...

by Douglas J. Hermes, Ian R. Jacobs, Megan C. Key, Alexis F. League, Barkha J. Yadav-Samudrala, Changqing Xu, Virginia D. McLane, Sara R. Nass, Wei Jiang, Rick B. Meeker, Bogna M. Ignatowska-Jankowska, Aron H. Lichtman, Zibo Li, Zhanhong Wu, Hong Yuan, Pamela E. Knapp, Kurt F. Hauser, Sylvia Fitting
Published 2020-11-01