Albright hereditary osteodystrophy Albright syndrome Article G protein G protein coupled receptor GNAS GPCR adult allele body mass brachydactyly case report clinical article computer assisted tomography female genetic variability genodermatoses genotype phenotype correlation guanine nucleotide binding protein high throughput sequencing hirsutism human human tissue illumina sequencing indel mutation leukocyte obesity protein serine threonine kinase pseudopseudohypoparathyroidism punch biopsy