Article EuroSCORE acetylsalicylic acid adult cardiopulmonary bypass controlled study double blind procedure drug blood level enoxaparin erythrocyte transfusion experimental therapy female follow up heart muscle revascularization human intraoperative period low molecular weight heparin major clinical study male mass spectrometry outcome assessment perioperative period postoperative hemorrhage postoperative period prospective study randomized controlled trial safety thorax surgery thrombocyte transfusion ticagrelor