APOB gene Article Cholesterol, LDL Female Humans Hyperlipoproteinemia Type II Hypolipidemic Agents LDLR gene Male Middle Aged Mutation PCSK9 gene PCSK9 inhibitor PCSK9 protein, human Proprotein Convertase 9 adult antilipemic agent axon blood clinical effectiveness clinical feature colestilan drug effect drug efficacy drug response ezetimibe familial hypercholesterolemia female gain of function mutation gain-of-function mutation