Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes

by Raghvendra Vishwakarma, Kirk J. McManus
Published 2020-03-01

A novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cells.

by Laura L Thompson, Kirk J McManus
Published 2015-01-01

Developing Targeted Therapies That Exploit Aberrant Histone Ubiquitination in Cancer

by Lucile M-P Jeusset, Kirk J McManus
Published 2019-02-01

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer

by Lucile M-P. Jeusset, Kirk J. McManus
Published 2017-12-01

Synthetic Genetic Targeting of Genome Instability in Cancer

by Kirk J. McManus, Brent J. Guppy, Babu V. Sajesh
Published 2013-06-01

Reduced <i>SKP1</i> Expression Induces Chromosome Instability through Aberrant Cyclin E1 Protein Turnover

by Laura L. Thompson, Allison K. Baergen, Zelda Lichtensztejn, Kirk J. McManus
Published 2020-02-01

An Automated, Single Cell Quantitative Imaging Microscopy Approach to Assess Micronucleus Formation, Genotoxicity and Chromosome Instability

by Chloe C. Lepage, Laura L. Thompson, Bradley Larson, Kirk J. McManus
Published 2020-02-01

Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis

by Allison K. Baergen, Lucile M. Jeusset, Zelda Lichtensztejn, Kirk J. McManus
Published 2019-07-01

The SCF Complex Is Essential to Maintain Genome and Chromosome Stability

by Laura L. Thompson, Kailee A. Rutherford, Chloe C. Lepage, Kirk J. McManus
Published 2021-08-01

Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers

by Amy L. Cisyk, Zoann Nugent, Robert H. Wightman, Harminder Singh, Kirk J. McManus
Published 2018-09-01

Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer

by Laura L. Thompson, Lucile M-P. Jeusset, Chloe C. Lepage, Kirk J. McManus
Published 2017-11-01

Reduced <i>USP22</i> Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis

by Lucile M. Jeusset, Brent J. Guppy, Zelda Lichtensztejn, Darin McDonald, Kirk J. McManus
Published 2021-03-01

Detecting Chromosome Instability in Cancer: Approaches to Resolve Cell-to-Cell Heterogeneity

by Chloe C. Lepage, Claire R. Morden, Michaela C. L. Palmer, Mark W. Nachtigal, Kirk J. McManus
Published 2019-02-01

The transcriptional regulator CBP has defined spatial associations within interphase nuclei.

by Kirk J McManus, David A Stephens, Niall M Adams, Suhail A Islam, Paul S Freemont, Michael J Hendzel
Published 2006-10-01

The temporal dynamics of chromosome instability in ovarian cancer cell lines and primary patient samples.

by Signe Penner-Goeke, Zelda Lichtensztejn, Megan Neufeld, Jennifer L Ali, Alon D Altman, Mark W Nachtigal, Kirk J McManus
Published 2017-04-01

Correction: An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

by Derek M. van Pel, Irene J. Barrett, Yoko Shimizu, Babu V. Sajesh, Brent J. Guppy, Tom Pfeifer, Kirk J. McManus, Philip Hieter
Published 2013-02-01

An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.

by Derek M van Pel, Irene J Barrett, Yoko Shimizu, Babu V Sajesh, Brent J Guppy, Tom Pfeifer, Kirk J McManus, Philip Hieter
Published 2013-01-01

Correction: An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development.

by Derek M. van Pel, Irene J. Barrett, Yoko Shimizu, Babu V. Sajesh, Brent J. Guppy, Tom Pfeifer, Kirk J. McManus, Philip Hieter
Published 2013-02-01

<i>RUNX3</i> Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis

by Karolin Heinze, Martin Hölzer, Martin Ungelenk, Melanie Gerth, Jürgen Thomale, Regine Heller, Claire R. Morden, Kirk J. McManus, Alexander S. Mosig, Matthias Dürst, Ingo B. Runnebaum, Norman Häfner
Published 2021-01-01

Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A.

by Jessica C Price, Lana M Pollock, Meghan L Rudd, Sarah K Fogoros, Hassan Mohamed, Christin L Hanigan, Matthieu Le Gallo, NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Suiyuan Zhang, Pedro Cruz, Praveen F Cherukuri, Nancy F Hansen, Kirk J McManus, Andrew K Godwin, Dennis C Sgroi, James C Mullikin, Maria J Merino, Philip Hieter, Daphne W Bell
Published 2014-01-01