Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease.

by Jennifer Riley, Stephen Brand, Michael Voice, Ivan Caballero, David Calvo, Kevin D Read
Published 2015-09-01

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo.

by Katrin Hack, Louise Reilly, Colin Palmer, Kevin D Read, Suzanne Norval, Robert Kime, Kally Booth, John Foerster
Published 2012-01-01

Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania.

by Susan Wyllie, Adam J Roberts, Suzanne Norval, Stephen Patterson, Bernardo J Foth, Matthew Berriman, Kevin D Read, Alan H Fairlamb
Published 2016-11-01

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on t...

by Andrew M. Brandon, Lysbeth H. Antonides, Jennifer Riley, Ola Epemolu, Denise A. McKeown, Kevin D. Read, Craig McKenzie
Published 2021-03-01

The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

by Stephen Patterson, Susan Wyllie, Suzanne Norval, Laste Stojanovski, Frederick RC Simeons, Jennifer L Auer, Maria Osuna-Cabello, Kevin D Read, Alan H Fairlamb
Published 2016-05-01

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

by Julianty Frost, Carles Galdeano, Pedro Soares, Morgan S. Gadd, Katarzyna M. Grzes, Lucy Ellis, Ola Epemolu, Satoko Shimamura, Marcus Bantscheff, Paola Grandi, Kevin D. Read, Doreen A. Cantrell, Sonia Rocha, Alessio Ciulli
Published 2016-11-01

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

by Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field
Published 2018-02-01

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

by Villo Muha, Ritchie Williamson, Rachel Hills, Alison D. McNeilly, Thomas G. McWilliams, Jana Alonso, Marianne Schimpl, Aneika C. Leney, Albert J. R. Heck, Calum Sutherland, Kevin D. Read, Rory J. McCrimmon, Simon P. Brooks, Daan M. F. van Aalten
Published 2019-11-01

Targeting N-myristoylation for therapy of B-cell lymphomas

by Erwan Beauchamp, Megan C. Yap, Aishwarya Iyer, Maneka A. Perinpanayagam, Jay M. Gamma, Krista M. Vincent, Manikandan Lakshmanan, Anandhkumar Raju, Vinay Tergaonkar, Soo Yong Tan, Soon Thye Lim, Wei-Feng Dong, Lynne M. Postovit, Kevin D. Read, David W. Gray, Paul G. Wyatt, John R. Mackey, Luc G. Berthiaume
Published 2020-10-01

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.

by Federica Giordani, Daniel Paape, Isabel M Vincent, Andrew W Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J Morrison, Yvonne Freund, Michael J Witty, Rosemary Peter, Darren Y Edwards, Jonathan M Wilkes, Justin J J van der Hooft, Clément Regnault, Kevin D Read, David Horn, Mark C Field, Michael P Barrett
Published 2020-11-01