A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models

by Wen-Hsin Liu, Kerstin Völse, Daniela Senft, Irmela Jeremias
Published 2021-06-01

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

by Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias
Published 2020-09-01

Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML

by Julia M. Kempf, Sabrina Weser, Michael D. Bartoschek, Klaus H. Metzeler, Binje Vick, Tobias Herold, Kerstin Völse, Raphael Mattes, Manuela Scholz, Lucas E. Wange, Moreno Festini, Enes Ugur, Maike Roas, Oliver Weigert, Sebastian Bultmann, Heinrich Leonhardt, Gunnar Schotta, Wolfgang Hiddemann, Irmela Jeremias, Karsten Spiekermann
Published 2021-03-01

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

by Michela Carlet, Kerstin Völse, Jenny Vergalli, Martin Becker, Tobias Herold, Anja Arner, Daniela Senft, Vindi Jurinovic, Wen-Hsin Liu, Yuqiao Gao, Veronika Dill, Boris Fehse, Claudia D. Baldus, Lorenz Bastian, Lennart Lenk, Denis M. Schewe, Johannes W. Bagnoli, Binje Vick, Jan Philipp Schmid, Alexander Wilhelm, Rolf Marschalek, Philipp J. Jost, Cornelius Miething, Kristoffer Riecken, Marc Schmidt-Supprian, Vera Binder, Irmela Jeremias
Published 2021-09-01