Mislocalization, aggregation formation and defect in proteolysis in ALS

by Atsushi Tsubota, Hidenori Ichijo, Kengo Homma
Published 2016-05-01

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants

by Takao Fujisawa, Namiko Yamaguchi, Hisae Kadowaki, Yuka Tsukamoto, Naomi Tsuburaya, Atsushi Tsubota, Hiromitsu Takahashi, Isao Naguro, Yuji Takahashi, Jun Goto, Shoji Tsuji, Hideki Nishitoh, Kengo Homma, Hidenori Ichijo
Published 2015-10-01

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

by Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo
Published 2018-07-01