Mechanisms of the Metabolic Shift during Somatic Cell Reprogramming

by Ken Nishimura, Aya Fukuda, Koji Hisatake
Published 2019-05-01

Time-course transcriptome analysis of human cellular reprogramming from multiple cell types reveals the drastic change occurs between the mid phase and the late phase

by Akihiro Kuno, Ken Nishimura, Satoru Takahashi
Published 2018-01-01

Aesthetic Reconstruction of Fingers and Thumbs With the Vascularized Half–Big Toenail Flap With Minimum Donor Site Morbidity

by Koichi Kobayashi, MD, Naoko Masuyama, MD, Ken Nishimura, MD
Published 2020-07-01

Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene.

by Aya Fukuda, Miho Shimada, Tomoyoshi Nakadai, Ken Nishimura, Koji Hisatake
Published 2013-01-01

Outcomes and precautions of endoscopic submucosal dissection for undifferentiated-type early gastric cancer

by Yasuhiro Inokuchi, Maki Kobayashi, Kana Kudo, Hiroaki Yamada, Shuntaro Inoue, Ken Nishimura, Norisuke Nakayama, Osamu Motohashi
Published 2015-09-01

Live cell imaging of X chromosome reactivation during somatic cell reprogramming

by Thi Hai Yen Tran, Aya Fukuda, Shiho Aizawa, Phuong Linh Bui, Yohei Hayashi, Ken Nishimura, Koji Hisatake
Published 2018-09-01

Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720.

by Aya Fukuda, Shiho Honda, Norie Fujioka, Yuya Sekiguchi, Seiya Mizuno, Yoshihiro Miwa, Fumihiro Sugiyama, Yohei Hayashi, Ken Nishimura, Koji Hisatake
Published 2019-01-01

Manipulation of KLF4 Expression Generates iPSCs Paused at Successive Stages of Reprogramming

by Ken Nishimura, Tetsuo Kato, Chen Chen, Lalhaba Oinam, Emi Shiomitsu, Daisuke Ayakawa, Manami Ohtaka, Aya Fukuda, Mahito Nakanishi, Koji Hisatake
Published 2014-11-01

An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils

by Huan-Ting Lin, Hideki Masaki, Tomoyuki Yamaguchi, Taizo Wada, Akihiro Yachie, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Hiromitsu Nakauchi, Makoto Otsu
Published 2015-01-01

Simple and effective generation of transgene-free induced pluripotent stem cells using an auto-erasable Sendai virus vector responding to microRNA-302

by Ken Nishimura, Manami Ohtaka, Hitomi Takada, Akira Kurisaki, Nhi Vo Kieu Tran, Yen Thi Hai Tran, Koji Hisatake, Masayuki Sano, Mahito Nakanishi
Published 2017-08-01

Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors

by Koichiro Nishino, Yoshikazu Arai, Ken Takasawa, Masashi Toyoda, Mayu Yamazaki-Inoue, Tohru Sugawara, Hidenori Akutsu, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Akihiro Umezawa
Published 2018-12-01

A Bile Duct Stone Formation around a Fish Bone as a Nidus after Pancreatoduodenectomy

by Tomoki Sakakida, Hideki Sato, Toshifumi Doi, Takumi Kawakami, Yoshikazu Nakatsugawa, Ken Nishimura, Shinya Yamada, Hideki Fujii, Naoya Tomatsuri, Yusuke Okuyama, Hiroyuki Kimura, Norimasa Yoshida
Published 2018-02-01

Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity

by Kenji Kubara, Kazuto Yamazaki, Yasuharu Ishihara, Takuya Naruto, Huan-Ting Lin, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Masashi Ito, Kappei Tsukahara, Tomohiro Morio, Masatoshi Takagi, Makoto Otsu
Published 2018-08-01

Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming

by Phuong Linh Bui, Ken Nishimura, Gonzalo Seminario Mondejar, Arun Kumar, Shiho Aizawa, Kensaku Murano, Kyosuke Nagata, Yohei Hayashi, Aya Fukuda, Yasuko Onuma, Yuzuru Ito, Mahito Nakanishi, Koji Hisatake
Published 2019-11-01

Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.

by Daigo Hasegawa, Hiromi Ochiai-Shino, Shoko Onodera, Takashi Nakamura, Akiko Saito, Takeshi Onda, Katsuhito Watanabe, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Kenjiro Kosaki, Akira Yamaguchi, Takahiko Shibahara, Toshifumi Azuma
Published 2017-01-01

4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates

by Katsuya Hirata, Toshihiko Nambara, Keiji Kawatani, Nobutoshi Nawa, Hidetaka Yoshimatsu, Haruna Kusakabe, Kimihiko Banno, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Hidetoshi Taniguchi, Hitomi Arahori, Kazuko Wada, Keiichi Ozono, Yasuji Kitabatake
Published 2020-08-01

A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation

by Ken Nishimura, Shiho Aizawa, Fransiska Liliani Nugroho, Emi Shiomitsu, Yen Thi Hai Tran, Phuong Linh Bui, Evgeniia Borisova, Yuta Sakuragi, Hitomi Takada, Akira Kurisaki, Yohei Hayashi, Aya Fukuda, Mahito Nakanishi, Koji Hisatake
Published 2017-03-01

Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts.

by Nobutoshi Nawa, Katsuya Hirata, Keiji Kawatani, Toshihiko Nambara, Sayaka Omori, Kimihiko Banno, Chikara Kokubu, Junji Takeda, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Daisuke Okuzaki, Hidetoshi Taniguchi, Hitomi Arahori, Kazuko Wada, Yasuji Kitabatake, Keiichi Ozono
Published 2019-01-01

A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy

by Miki Ando, Toshinobu Nishimura, Satoshi Yamazaki, Tomoyuki Yamaguchi, Ai Kawana-Tachikawa, Tomonari Hayama, Yusuke Nakauchi, Jun Ando, Yasunori Ota, Satoshi Takahashi, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, John J. Miles, Scott R. Burrows, Malcolm K. Brenner, Hiromitsu Nakauchi
Published 2015-10-01

Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model

by Akiko Saito, Akio Ooki, Takashi Nakamura, Shoko Onodera, Kamichika Hayashi, Daigo Hasegawa, Takahito Okudaira, Katsuhito Watanabe, Hiroshi Kato, Takeshi Onda, Akira Watanabe, Kenjiro Kosaki, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Teruo Sakamoto, Akira Yamaguchi, Kenji Sueishi, Toshifumi Azuma
Published 2018-01-01