Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

by Kelly L. Johnston, Louise Ford, Indira Umareddy, Simon Townson, Sabine Specht, Kenneth Pfarr, Achim Hoerauf, Ralf Altmeyer, Mark J. Taylor
Published 2014-12-01

Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial.

by Joseph D Turner, Nicholas Tendongfor, Mathias Esum, Kelly L Johnston, R Stuart Langley, Louise Ford, Brian Faragher, Sabine Specht, Sabine Mand, Achim Hoerauf, Peter Enyong, Samuel Wanji, Mark J Taylor
Published 2010-04-01

Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

by Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward
Published 2018-01-01

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

by Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D. Turner, Mark J. Taylor, Stephen A. Ward
Published 2017-03-01

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

by Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Published 2019-02-01

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides

by Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward
Published 2019-01-01