Administration, Oral Administration, Topical Alendronate Bisphosphonates Chronic Periodontitis Combined Modality Therapy Dental Scaling Diphosphonates Humans Review Root Planing alendronic acid bisphosphonic acid derivative bone defect cannula chronic periodontitis dental scaling diabetes mellitus drug efficacy human menopause meta analysis multimodality cancer therapy neridronic acid obesity oral drug administration outcome assessment periodontal abscess periodontal disease periodontal pocket