Retrospective analysis of cohort database: Phenotypic variability in a large dataset of patients confirmed to have homozygous familial hypercholesterolemia

by Frederick J. Raal, Barbara Sjouke, G. Kees Hovingh, Barton F. Isaac
Published 2016-06-01

High-density lipoprotein (HDL) particle subpopulations in heterozygous cholesteryl ester transfer protein (CETP) deficiency: maintenance of antioxidative activity.

by Sandrine Chantepie, Andrea E Bochem, M John Chapman, G Kees Hovingh, Anatol Kontush
Published 2012-01-01

The PCSK9 decade

by Gilles Lambert, Barbara Sjouke, Benjamin Choque, John J.P. Kastelein, G. Kees Hovingh
Published 2012-12-01

Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study1

by Rutger Verbeek, S. Matthijs Boekholdt, Robert M. Stoekenbroek, G. Kees Hovingh, Joseph L. Witztum, Nicholas J. Wareham, Manjinder S. Sandhu, Kay-Tee Khaw, Sotirios Tsimikas
Published 2016-04-01

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia

by G. Kees Hovingh, Michel J.A. van Wijland, Alison Brownlie, Radjesh J. Bisoendial, Michael R. Hayden, John J.P. Kastelein, Albert K. Groen
Published 2003-06-01

eNOS activation by HDL is impaired in genetic CETP deficiency.

by Monica Gomaraschi, Alice Ossoli, Silvia Pozzi, Peter Nilsson, Angelo B Cefalù, Maurizio Averna, Jan Albert Kuivenhoven, G Kees Hovingh, Fabrizio Veglia, Guido Franceschini, Laura Calabresi
Published 2014-01-01

Differential DNA methylation in familial hypercholesterolemia

by Laurens F. Reeskamp, Andrea Venema, Joao P.Belo Pereira, Evgeni Levin, Max Nieuwdorp, Albert K. Groen, Joep C. Defesche, Aldo Grefhorst, Peter Henneman, G.Kees Hovingh
Published 2020-11-01

Adrenal Function in females with low plasma HDL-C due to mutations in ABCA1 and LCAT.

by Andrea E Bochem, Adriaan G Holleboom, Johannes A Romijn, Menno Hoekstra, Geesje M Dallinga, Mahdi M Motazacker, G Kees Hovingh, Jan A Kuivenhoven, Erik S G Stroes
Published 2014-01-01

High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C

by Andrea E. Bochem, Adriaan G. Holleboom, Johannes A. Romijn, Menno Hoekstra, Geesje M. Dallinga-Thie, Mahdi M. Motazacker, G.Kees Hovingh, Jan A. Kuivenhoven, Erik S.G. Stroes
Published 2013-06-01

Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease

by Sander I. van Leuven, Rachel Hezemans, Johannes H. Levels, Susan Snoek, Pieter C. Stokkers, G. Kees Hovingh, John J.P. Kastelein, Erik S. Stroes, Eric de Groot, Daan W. Hommes
Published 2007-12-01

Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol.

by Ian Tietjen, G Kees Hovingh, Roshni R Singaraja, Chris Radomski, Amina Barhdadi, Jason McEwen, Elden Chan, Maryanne Mattice, Annick Legendre, Patrick L Franchini, Marie-Pierre Dubé, John J P Kastelein, Michael R Hayden
Published 2012-01-01

High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins

by Josefien W. Hommes, Rachel M. Kratofil, Sigrid Wahlen, Carla J. C. de Haas, Reeni B. Hildebrand, G. Kees Hovingh, Micheal Otto, Miranda van Eck, Menno Hoekstra, Suzanne J. A. Korporaal, Bas G. J. Surewaard
Published 2021-07-01

Monocyte gene expression signature of patients with early onset coronary artery disease.

by Suthesh Sivapalaratnam, Hanneke Basart, Nicholas A Watkins, Stepanie Maiwald, Augusto Rendon, Unni Krishnan, Brigitte M Sondermeijer, Esther E Creemers, Sara J Pinto-Sietsma, Kees Hovingh, Willem H Ouwehand, John J P Kastelein, Alison H Goodall, Mieke D Trip
Published 2012-01-01

Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasianss⃞

by Wim A. van der Steeg, G. Kees Hovingh, Anke H.E.M. Klerkx, Barbara A. Hutten, Inge C. Nootenboom, Johannes H.M. Levels, Arie van Tol, Gees M. Dallinga-Thie, Aeilko H. Zwinderman, John J.P. Kastelein, Jan Albert Kuivenhoven
Published 2007-03-01

In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1[S]

by Adriaan G. Holleboom, Lily Jakulj, Remco Franssen, Julie Decaris, Menno Vergeer, Joris Koetsveld, Jayraz Luchoomun, Alexander Glass, Marc K. Hellerstein, John J.P. Kastelein, G. Kees Hovingh, Jan Albert Kuivenhoven, Albert K. Groen, Scott M. Turner, Erik S.G. Stroes
Published 2013-07-01

Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans[S]

by Roshni R. Singaraja, Ian Tietjen, G. Kees Hovingh, Patrick L. Franchini, Chris Radomski, Kenny Wong, Margaret vanHeek, Ioannis M. Stylianou, Linus Lin, Liangsu Wang, Lyndon Mitnaul, Brian Hubbard, Michael Winther, Maryanne Mattice, Annick Legendre, Robin Sherrington, John J. Kastelein, Karen Akinsanya, Andrew Plump, Michael R. Hayden
Published 2014-08-01

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA[S]

by Ruud S. Kootte, Loek P. Smits, Fleur M. van der Valk, Jean-Louis Dasseux, Constance H. Keyserling, Ronald Barbaras, John F. Paolini, Raul D. Santos, Theo H. van Dijk, Geesje M. Dallinga-van Thie, Aart J. Nederveen, WillemJ.M. Mulder, G.Kees Hovingh, JohnJ.P. Kastelein, Albert K. Groen, ErikS. Stroes
Published 2015-03-01

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

by Cheryl L. Wellington, Yu-Zhou Yang, Stephen Zhou, Susanne M. Clee, Bing Tan, Kenichi Hirano, Karin Zwarts, Anita Kwok, Allison Gelfer, Michel Marcil, Scott Newman, Kirsten Roomp, Roshni Singaraja, Jennifer Collins, Lin-Hua Zhang, Albert K. Groen, Kees Hovingh, Alison Brownlie, Sherrie Tafuri, Jacques Genest, Jr., John J.P. Kastelein, Michael R. Hayden
Published 2002-11-01

Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.

by Stephanie Maiwald, Suthesh Sivapalaratnam, Mahdi M Motazacker, Julian C van Capelleveen, Ilze Bot, Saskia C de Jager, Miranda van Eck, Jennifer Jolley, Johan Kuiper, Jonathon Stephens, Cornelius A Albers, C Ruben Vosmeer, Heleen Kruize, Daan P Geerke, Allard C van der Wal, Chris M van der Loos, John J P Kastelein, Mieke D Trip, Willem H Ouwehand, Geesje M Dallinga-Thie, G Kees Hovingh
Published 2014-01-01

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

by Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hypponen, Christine Power, Max Moldovan, Erik van Iperen, Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Christina M. Lill, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F. Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G. Panayiotou, N. Charlotte Onland-Moret, Yvonne T. van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J. Wareham, Claudia Langenberg, Robert A. Scott, Jian’an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Tine Jess, Jackie Cooper, Steve E. Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S. Carrell, Catherine A. McCarty, Kirchner H. Lester, Eric B. Larson, David R. Crosslin, Mariza de Andrade, Dan M. Roden, Joshua C. Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Rodney Scott, Peter Schofield, Martin O’Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M. Abdullah Said, Ruben N. Eppinga, Niek Verweij, Harold Snieder, Lifelines Cohort authors, Tim Christen, D. O. Mook-Kanamori, the ICBP Consortium, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M. Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P. Pell, Tom Meade, Ingrid E. Christophersen, Anke H. Maitland-van der Zee, Ekaterina V. Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L. Bots, Diederick E. Grobbee, Philippe Froguel, Dorothée Thuillier, Ronan Roussel, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Jemma C. Hopewell, Sudha Seshadri, the METASTROKE Consortium of the ISGC, Caroline Dale, Rui Providencia E. Costa, Paul M. Ridker, Daniel I. Chasman, Alex P. Reiner, Marylyn D. Ritchie, Leslie A. Lange, Alex J. Cornish, Sara E. Dobbins, Kari Hemminki, Ben Kinnersley, Marc Sanson, Karim Labreche, Matthias Simon, Melissa Bondy, Philip Law, Helen Speedy, James Allan, Ni Li, Molly Went, Niels Weinhold, Gareth Morgan, Pieter Sonneveld, Björn Nilsson, Hartmut Goldschmidt, Amit Sud, Andreas Engert, Markus Hansson, Harry Hemingway, Folkert W. Asselbergs, Riyaz S. Patel, Brendan J. Keating, Naveed Sattar, Richard Houlston, Juan P. Casas, Aroon D. Hingorani
Published 2019-10-01