Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains.

by Tomoyuki Yamanaka, Asako Tosaki, Masaru Kurosawa, Kazunori Akimoto, Tomonori Hirose, Shigeo Ohno, Nobutaka Hattori, Nobuyuki Nukina
Published 2013-01-01

An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms.

by Tomonori Hirose, Daisuke Satoh, Hidetake Kurihara, Chiho Kusaka, Hiroko Hirose, Kazunori Akimoto, Taiji Matsusaka, Iekuni Ichikawa, Tetsuo Noda, Shigeo Ohno
Published 2009-01-01

Generation of two human induced pluripotent stem cell lines derived from two X-linked adrenoleukodystrophy patients with ABCD1 mutations

by Yuji Kuramochi, Tomonari Awaya, Mami Matsuo-Takasaki, Miho Takami, Yuri An, Jingyue Li, Yasuko Hemmi, Tamami Wakabayashi, Yutaka Arai, Jun Inoue, Michiya Noguchi, Yukio Nakamura, Isao Asaka, Kazunori Akimoto, Megumu K. Saito, Yohei Hayashi
Published 2021-05-01

High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients.

by Yuka Nozaki, Hitomi Motomura, Shoma Tamori, Yumiko Kimura, Chotaro Onaga, Shotaro Kanai, Yuka Ishihara, Ayaka Ozaki, Yasushi Hara, Yohsuke Harada, Yasunari Mano, Tsugumichi Sato, Keiko Sato, Kazunori Sasaki, Hitoshi Ishiguro, Shigeo Ohno, Kazunori Akimoto
Published 2020-01-01