Transcriptome Profiling and Metagenomic Analysis Help to Elucidate Interactions in an Inflammation-Associated Cancer Mouse Model

by Kazuko Sakai, Marco A. De Velasco, Yurie Kura, Kazuto Nishio
Published 2021-07-01

New Era for Next-Generation Sequencing in Japan

by Masayuki Takeda, Kazuko Sakai, Takayuki Takahama, Kazuya Fukuoka, Kazuhiko Nakagawa, Kazuto Nishio
Published 2019-05-01

Durable response to EGFR tyrosine kinase inhibitors in a patient with non–small cell lung cancer harboring an EGFR kinase domain duplication

by Esuteru Hirokawa, Satomi Watanabe, Kazuko Sakai, Masayuki Takeda, Chihiro Sato, Takayuki Takahama, Kazuto Nishio, Kazuhiko Nakagawa
Published 2021-08-01

Comprehensive Gene Mutation Profiling of Circulating Tumor DNA in Ovarian Cancer: Its Pathological and Prognostic Impact

by Tomoko Noguchi, Naoyuki Iwahashi, Kazuko Sakai, Kaho Matsuda, Hitomi Matsukawa, Saori Toujima, Kazuto Nishio, Kazuhiko Ino
Published 2020-11-01

Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression.

by Katsuaki Sato, Kenichi Suda, Shigeki Shimizu, Kazuko Sakai, Hiroshi Mizuuchi, Kenji Tomizawa, Toshiki Takemoto, Kazuto Nishio, Tetsuya Mitsudomi
Published 2016-01-01

Development of on-chip multi-imaging flow cytometry for identification of imaging biomarkers of clustered circulating tumor cells.

by Hyonchol Kim, Hideyuki Terazono, Yoshiyasu Nakamura, Kazuko Sakai, Akihiro Hattori, Masao Odaka, Mathias Girault, Tokuzo Arao, Kazuto Nishio, Yohei Miyagi, Kenji Yasuda
Published 2014-01-01

Association between Genetic and Immunological Background of Hepatocellular Carcinoma and Expression of Programmed Cell Death-1

by Naoshi Nishida, Kazuko Sakai, Masahiro Morita, Tomoko Aoki, Masahiro Takita, Satoru Hagiwara, Yoriaki Komeda, Mamoru Takenaka, Yasunori Minami, Hiroshi Ida, Kazuomi Ueshima, Kazuto Nishio, Masatoshi Kudo
Published 2020-03-01

Efficacy of irreversible EGFR-TKIs for the uncommon secondary resistant EGFR mutations L747S, D761Y, and T854A

by Masato Chiba, Yosuke Togashi, Eri Bannno, Yoshihisa Kobayashi, Yu Nakamura, Hidetoshi Hayashi, Masato Terashima, Marco A. De Velasco, Kazuko Sakai, Yoshihiko Fujita, Tetsuya Mitsudomi, Kazuto Nishio
Published 2017-04-01

Context-Specific Efficacy of Apalutamide Therapy in Preclinical Models of <i>Pten</i>-Deficient Prostate Cancer

by Marco A. De Velasco, Yurie Kura, Naomi Ando, Noriko Sako, Eri Banno, Kazutoshi Fujita, Masahiro Nozawa, Kazuhiro Yoshimura, Kazuko Sakai, Kazuhiro Yoshikawa, Kazuto Nishio, Hirotsugu Uemura
Published 2021-08-01

Extended RAS and BRAF Mutation Analysis Using Next-Generation Sequencing.

by Kazuko Sakai, Junji Tsurutani, Takeharu Yamanaka, Azusa Yoneshige, Akihiko Ito, Yosuke Togashi, Marco A De Velasco, Masato Terashima, Yoshihiko Fujita, Shuta Tomida, Takao Tamura, Kazuhiko Nakagawa, Kazuto Nishio
Published 2015-01-01

Immunological Microenvironment Predicts the Survival of the Patients with Hepatocellular Carcinoma Treated with Anti-PD-1 Antibody

by Masahiro Morita, Naoshi Nishida, Kazuko Sakai, Tomoko Aoki, Hirokazu Chishina, Masahiro Takita, Hiroshi Ida, Satoru Hagiwara, Yasunori Minami, Kazuomi Ueshima, Kazuto Nishio, Yukari Kobayashi, Kazuhiro Kakimi, Masatoshi Kudo
Published 2021-06-01

Clinical and immune profiling for cancer of unknown primary site

by Koji Haratani, Hidetoshi Hayashi, Takayuki Takahama, Yasushi Nakamura, Shuta Tomida, Takeshi Yoshida, Yasutaka Chiba, Takahiro Sawada, Kazuko Sakai, Yoshihiko Fujita, Yosuke Togashi, Junko Tanizaki, Hisato Kawakami, Akihiko Ito, Kazuto Nishio, Kazuhiko Nakagawa
Published 2019-09-01

Predicting osimertinib‐treatment outcomes through EGFR mutant‐fraction monitoring in the circulating tumor DNA of EGFR T790M‐positive patients with non‐small cell lung cancer (WJOG...

by Kazuko Sakai, Takayuki Takahama, Mototsugu Shimokawa, Koichi Azuma, Masayuki Takeda, Terufumi Kato, Haruko Daga, Isamu Okamoto, Hiroaki Akamatsu, Shunsuke Teraoka, Akira Ono, Tatsuo Ohira, Toshihide Yokoyama, Nobuyuki Yamamoto, Kazuhiko Nakagawa, Kazuto Nishio
Published 2021-01-01

A microarray-based gene expression analysis to identify diagnostic biomarkers for unknown primary cancer.

by Issei Kurahashi, Yoshihiko Fujita, Tokuzo Arao, Takayasu Kurata, Yasuhiro Koh, Kazuko Sakai, Koji Matsumoto, Maki Tanioka, Koji Takeda, Yuichi Takiguchi, Nobuyuki Yamamoto, Asuka Tsuya, Nobuaki Matsubara, Hirofumi Mukai, Hironobu Minami, Naoko Chayahara, Yasuhiro Yamanaka, Keisuke Miwa, Shin Takahashi, Shunji Takahashi, Kazuhiko Nakagawa, Kazuto Nishio
Published 2013-01-01

Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research study

by Cecily P. Vaughn, José Luis Costa, Harriet E. Feilotter, Rosella Petraroli, Varun Bagai, Anna Maria Rachiglio, Federica Zito Marino, Bastiaan Tops, Henriette M. Kurth, Kazuko Sakai, Andrea Mafficini, Roy R. L. Bastien, Anne Reiman, Delphine Le Corre, Alexander Boag, Susan Crocker, Michel Bihl, Astrid Hirschmann, Aldo Scarpa, José Carlos Machado, Hélène Blons, Orla Sheils, Kelli Bramlett, Marjolijn J. L. Ligtenberg, Ian A. Cree, Nicola Normanno, Kazuto Nishio, Pierre Laurent-Puig
Published 2018-08-01

High Incidence of C797S Mutation in Patients With Long Treatment History of EGFR Tyrosine Kinase Inhibitors Including Osimertinib

by Atsushi Osoegawa, MD, PhD, Masafumi Yamaguchi, MD, PhD, Tomomi Nakamura, MD, PhD, Ryotaro Morinaga, MD, Kentaro Tanaka, MD, PhD, Kosuke Kashiwabara, MD, PhD, Takashi Miura, MD, PhD, Takayuki Suetsugu, MD, PhD, Taishi Harada, MD, PhD, Tatsuma Asoh, MD, PhD, Kenichi Taguchi, MD, PhD, Kazuki Nabeshima, MD, PhD, Junji Kishimoto, MA, Kazuko Sakai, PhD, Kazuto Nishio, MD, PhD, Kenji Sugio, MD, PhD
Published 2021-07-01

Ramucirumab Plus Erlotinib Versus Placebo Plus Erlotinib in Patients With Untreated Metastatic EGFR-Mutated NSCLC: RELAY Japanese Subset

by Kazuto Nishio, MD, PhD, Takashi Seto, MD, Makoto Nishio, MD, PhD, Martin Reck, MD, PhD, Edward B. Garon, MD, MS, Kazuko Sakai, PhD, Koichi Goto, MD, PhD, Terufumi Kato, MD, Yoichi Nakanishi, MD, PhD, Toshiaki Takahashi, MD, PhD, Nobuyuki Yamamoto, MD, PhD, Katsuyuki Kiura, MD, PhD, Yuichiro Ohe, MD, PhD, Tomohide Tamura, MD, Carla Visseren-Grul, MD, Bente Frimodt-Moller, MSc, Rebecca R. Hozak, PhD, Sameera R. Wijayawardana, PhD, Annamaria Zimmermann, MS, Gosuke Homma, PhD, Sotaro Enatsu, MD, PhD, Kazuhiko Nakagawa, MD, PhD
Published 2021-06-01