Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

by Tural Aksel, Elizabeth Choe Yu, Shirley Sutton, Kathleen M. Ruppel, James A. Spudich
Published 2015-05-01

Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.

by Ruth F Sommese, Suman Nag, Shirley Sutton, Susan M Miller, James A Spudich, Kathleen M Ruppel
Published 2013-01-01

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

by Arjun S. Adhikari, Darshan V. Trivedi, Saswata S. Sarkar, Dan Song, Kristina B. Kooiker, Daniel Bernstein, James A. Spudich, Kathleen M. Ruppel
Published 2019-06-01