CD4+ T Cells Modified by the Endoribonuclease MazF Are Safe and Can Persist in SHIV-infected Rhesus Macaques

by Naoki Saito, Hideto Chono, Hiroaki Shibata, Naohide Ageyama, Yasuhiro Yasutomi, Junichi Mineno
Published 2014-01-01

129 A novel CAR conducting antigen-specific JAK-STAT signals demonstrates superior antitumor effects with minimal undesired non-specific activation

by Sachiko Okamoto, Junichi Mineno, Naoto Hirano, Yasunori Amaishi, Yu Okubo, Mitsuki Shigeta, Yota Ohashi
Published 2020-11-01

An efficient large-scale retroviral transduction method involving preloading the vector into a RetroNectin-coated bag with low-temperature shaking.

by Katsuyuki Dodo, Hideto Chono, Naoki Saito, Yoshinori Tanaka, Kenichi Tahara, Ikuei Nukaya, Junichi Mineno
Published 2014-01-01

Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induc...

by Mikiya Ishihara, Naohiro Seo, Jun Mitsui, Daisuke Muraoka, Maki Tanaka, Junichi Mineno, Hiroaki Ikeda, Hiroshi Shiku
Published 2014-01-01

A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.

by Nicholas Paul Casey, Hiroshi Fujiwara, Kazushi Tanimoto, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa
Published 2016-01-01

Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor

by Ryosuke Uchibori, Takeshi Teruya, Hiroyuki Ido, Ken Ohmine, Yoshihide Sehara, Masashi Urabe, Hiroaki Mizukami, Junichi Mineno, Keiya Ozawa
Published 2019-03-01

In vivo safety and persistence of endoribonuclease gene-transduced CD4+ T cells in cynomolgus macaques for HIV-1 gene therapy model.

by Hideto Chono, Naoki Saito, Hiroshi Tsuda, Hiroaki Shibata, Naohide Ageyama, Keiji Terao, Yasuhiro Yasutomi, Junichi Mineno, Ikunoshin Kato
Published 2011-01-01

A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression

by Sachiko Okamoto, Yasunori Amaishi, Yumi Goto, Hiroaki Ikeda, Hiroshi Fujiwara, Kiyotaka Kuzushima, Masaki Yasukawa, Hiroshi Shiku, Junichi Mineno
Published 2012-01-01

Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.

by Hiroaki Asai, Hiroshi Fujiwara, Jun An, Toshiki Ochi, Yukihiro Miyazaki, Kozo Nagai, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Hirofumi Inoue, Masaki Yasukawa
Published 2013-01-01

Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9

by Taro Tomono, Yukihiko Hirai, Hironori Okada, Yoshitaka Miyagawa, Kumi Adachi, Shuhei Sakamoto, Yasuhiro Kawano, Hideto Chono, Junichi Mineno, Akiko Ishii, Takashi Shimada, Masafumi Onodera, Akira Tamaoka, Takashi Okada
Published 2018-12-01

Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer.

by Takeshi Ishikawa, Satoshi Kokura, Tatsuji Enoki, Naoyuki Sakamoto, Tetsuya Okayama, Mitsuko Ideno, Junichi Mineno, Kazuko Uno, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa
Published 2014-01-01

Integrative immunogenomic analysis of gastric cancer dictates novel immunological classification and the functional status of tumor‐infiltrating cells

by Yasuyoshi Sato, Ikuo Wada, Kosuke Odaira, Akihiro Hosoi, Yukari Kobayashi, Koji Nagaoka, Takahiro Karasaki, Hirokazu Matsushita, Koichi Yagi, Hiroharu Yamashita, Masashi Fujita, Shuichi Watanabe, Takashi Kamatani, Fuyuki Miya, Junichi Mineno, Hidewaki Nakagawa, Tatsuhiko Tsunoda, Shunji Takahashi, Yasuyuki Seto, Kazuhiro Kakimi
Published 2020-01-01