Probing the mutational interplay between primary and promiscuous protein functions: a computational-experimental approach.

by Hector Garcia-Seisdedos, Beatriz Ibarra-Molero, Jose M Sanchez-Ruiz
Published 2012-01-01

Using Resurrected Ancestral Proviral Proteins to Engineer Virus Resistance

by Asunción Delgado, Rocio Arco, Beatriz Ibarra-Molero, Jose M. Sanchez-Ruiz
Published 2017-05-01

Consensus Design of an Evolved High-Redox Potential Laccase

by Bernardo J. Gomez-Fernandez, Valeria A. Risso, Jose M. Sanchez-Ruiz, Miguel Alcalde
Published 2020-05-01

Highly anomalous energetics of protein cold denaturation linked to folding-unfolding kinetics.

by M Luisa Romero-Romero, Alvaro Inglés-Prieto, Beatriz Ibarra-Molero, Jose M Sanchez-Ruiz
Published 2011-01-01

A protocol to study bacteriophage adaptation to new hosts

by Raquel Luzon-Hidalgo, Valeria A. Risso, Asuncion Delgado, Beatriz Ibarra-Molero, Jose M. Sanchez-Ruiz
Published 2021-09-01

Evidence for a role of phenotypic mutations in virus adaptation

by Raquel Luzon-Hidalgo, Valeria A. Risso, Asuncion Delgado, Eduardo Andrés-León, Beatriz Ibarra-Molero, Jose M. Sanchez-Ruiz
Published 2021-04-01

Selection for Protein Kinetic Stability Connects Denaturation Temperatures to Organismal Temperatures and Provides Clues to Archaean Life.

by M Luisa Romero-Romero, Valeria A Risso, Sergio Martinez-Rodriguez, Eric A Gaucher, Beatriz Ibarra-Molero, Jose M Sanchez-Ruiz
Published 2016-01-01

Mechanism of protein kinetic stabilization by engineered disulfide crosslinks.

by Inmaculada Sanchez-Romero, Antonio Ariza, Keith S Wilson, Michael Skjøt, Jesper Vind, Leonardo De Maria, Lars K Skov, Jose M Sanchez-Ruiz
Published 2013-01-01

The peripheral binding of 14-3-3γ to membranes involves isoform-specific histidine residues.

by Helene J Bustad, Lars Skjaerven, Ming Ying, Øyvind Halskau, Anne Baumann, David Rodriguez-Larrea, Miguel Costas, Jarl Underhaug, Jose M Sanchez-Ruiz, Aurora Martinez
Published 2012-01-01

Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

by Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan
Published 2021-03-01

Engineering protein assemblies with allosteric control via monomer fold-switching

by Luis A. Campos, Rajendra Sharma, Sara Alvira, Federico M. Ruiz, Beatriz Ibarra-Molero, Mourad Sadqi, Carlos Alfonso, Germán Rivas, Jose M. Sanchez-Ruiz, Antonio Romero Garrido, José M. Valpuesta, Victor Muñoz
Published 2019-12-01

De novo active sites for resurrected Precambrian enzymes

by Valeria A. Risso, Sergio Martinez-Rodriguez, Adela M. Candel, Dennis M. Krüger, David Pantoja-Uceda, Mariano Ortega-Muñoz, Francisco Santoyo-Gonzalez, Eric A. Gaucher, Shina C. L. Kamerlin, Marta Bruix, Jose A. Gavira, Jose M. Sanchez-Ruiz
Published 2017-07-01

Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

by Gloria Gamiz-Arco, Luis I. Gutierrez-Rus, Valeria A. Risso, Beatriz Ibarra-Molero, Yosuke Hoshino, Dušan Petrović, Jose Justicia, Juan Manuel Cuerva, Adrian Romero-Rivera, Burckhard Seelig, Jose A. Gavira, Shina C. L. Kamerlin, Eric A. Gaucher, Jose M. Sanchez-Ruiz
Published 2021-01-01