Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

by Fabian Arenas, Fabian Arenas, Fabian Arenas, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa
Published 2017-11-01

Mitochondrial Oxidative Stress and Antioxidants Balance in Fatty Liver Disease

by Carmen García‐Ruiz, José C. Fernández‐Checa
Published 2018-12-01

Alcohol-induced liver disease: when fat and oxidative stress meet

by José C. Fernández-Checa, MD, PhD
Published 2003-04-01

Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease

by Sandra Torres, Sandra Torres, Carmen M. García-Ruiz, Carmen M. García-Ruiz, Carmen M. García-Ruiz, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa
Published 2019-11-01

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease

by Sandra Torres, Sandra Torres, Elisa Balboa, Silvana Zanlungo, Carlos Enrich, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa
Published 2017-11-01

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

by Anna Moles, Anna Moles, Sandra Torres, Sandra Torres, Anna Baulies, Anna Baulies, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa
Published 2018-05-01

Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes

by Olga Coll, Albert Morales, José C. Fernández-Checa, Carmen Garcia-Ruiz
Published 2007-09-01

Editorial: Autophagy and Related Transcription Factors in Liver and Gut Diseases

by Nabil Eid, Manoj B. Menon, Paul Thomes, Tao Zeng, Nuno Raimundo, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Lin Wang, Yuko Ito, Yoshinori Otsuki, Ernest Adeghate
Published 2020-01-01

Sphingomyelinases and Liver Diseases

by Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa
Published 2020-10-01

Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress

by Montserrat Marí, Albert Morales, Anna Colell, Carmen García-Ruiz, Jose C. Fernández-Checa
Published 2014-01-01

GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.

by Josep M Lluis, Laura Llacuna, Claudia von Montfort, Cristina Bárcena, Carlos Enrich, Albert Morales, José C Fernandez-Checa
Published 2009-11-01

Cholesterol Induces Nrf-2- and HIF-1α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis

by Yula Kaminsky-Kolesnikov, Einat Rauchbach, Diana Abu-Halaka, Michal Hahn, Carmen García-Ruiz, Jose C. Fernandez-Checa, Zecharia Madar, Oren Tirosh
Published 2020-01-01

Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes

by Estel Solsona-Vilarrasa, Raquel Fucho, Sandra Torres, Susana Nuñez, Natalia Nuño-Lámbarri, Carlos Enrich, Carmen García-Ruiz, José C. Fernández-Checa
Published 2019-06-01

Consumption of decaffeinated coffee protects against the development of early non-alcoholic steatohepatitis: Role of intestinal barrier function

by Annette Brandt, Anika Nier, Cheng Jun Jin, Anja Baumann, Finn Jung, Vicent Ribas, Carmen García-Ruiz, Jose C. Fernández-Checa, Ina Bergheim
Published 2019-02-01

Dietary and Genetic Cholesterol Loading Rather Than Steatosis Promotes Liver Tumorigenesis and NASH-Driven HCC

by Vicent Ribas, Laura Conde de la Rosa, David Robles, Susana Núñez, Paula Segalés, Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, José C. Fernández-Checa, Carmen García-Ruiz
Published 2021-08-01

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content

by Elisa Balboa, Juan Castro, María-José Pinochet, Gonzalo I. Cancino, Nuria Matías, Pablo José Sáez, Alexis Martínez, Alejandra R. Álvarez, Carmen Garcia-Ruiz, José C. Fernandez-Checa, Silvana Zanlungo
Published 2017-08-01

Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation

by Sandra Torres, Estel Solsona-Vilarrasa, Susana Nuñez, Nuria Matías, Naroa Insausti-Urkia, Fernanda Castro, Mireia Casasempere, Gemma Fabriás, Josefina Casas, Carlos Enrich, José C. Fernández-Checa, Carmen Garcia-Ruiz
Published 2021-09-01

Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase.

by Sandra Angulo, Albert Morales, Silvio Danese, Laura Llacuna, Maria Carme Masamunt, Nicole Pultz, Maria Grazia Cifone, Claudio De Simone, Salvadora Delgado, Jordi Vila, Julián Panés, Curtis Donskey, Jose C Fernández-Checa, Claudio Fiocchi, Miquel Sans
Published 2011-03-01

Liver Cholesterol Overload Aggravates Obstructive Cholestasis by Inducing Oxidative Stress and Premature Death in Mice

by Natalia Nuño-Lámbarri, Mayra Domínguez-Pérez, Anna Baulies-Domenech, Maria J. Monte, Jose J. G. Marin, Patricia Rosales-Cruz, Verónica Souza, Roxana U. Miranda, Leticia Bucio, Eduardo E. Montalvo-Jave, María Concepción Gutiérrez-Ruiz, Carmen García-Ruiz, José C. Fernández-Checa, Luis Enrique Gomez-Quiroz
Published 2016-01-01

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease

by Sandra Torres, Nuria Matías, Anna Baulies, Susana Nuñez, Cristina Alarcon-Vila, Laura Martinez, Natalia Nuño, Anna Fernandez, Joan Caballeria, Thierry Levade, Alba Gonzalez-Franquesa, Pablo Garcia-Rovés, Elisa Balboa, Silvana Zanlungo, Gemma Fabrías, Josefina Casas, Carlos Enrich, Carmen Garcia-Ruiz, José C. Fernández-Checa
Published 2017-04-01