Continuous Cultivation as a Tool Toward the Rational Bioprocess Development With Pichia Pastoris Cell Factory

by Miguel Angel Nieto-Taype, Xavier Garcia-Ortega, Joan Albiol, José Luis Montesinos-Seguí, Francisco Valero
Published 2020-06-01

Specific growth rate governs AOX1 gene expression, affecting the production kinetics of Pichia pastoris (Komagataella phaffii) P AOX1 -driven recombinant producer strains with diff...

by Javier Garrigós-Martínez, Miguel Angel Nieto-Taype, Arnau Gasset-Franch, José Luis Montesinos-Seguí, Xavier Garcia-Ortega, Francisco Valero
Published 2019-11-01

Rationale‐based selection of optimal operating strategies and gene dosage impact on recombinant protein production in Komagataella phaffii (Pichia pastoris)

by Miguel Angel Nieto‐Taype, Javier Garrigós‐Martínez, Marc Sánchez‐Farrando, Francisco Valero, Xavier Garcia‐Ortega, José Luis Montesinos‐Seguí
Published 2020-03-01

Scalable production and application of Pichia pastoris whole cell catalysts expressing human cytochrome P450 2C9

by Javier Garrigós-Martínez, Astrid Weninger, José Luis Montesinos-Seguí, Christian Schmid, Francisco Valero, Claudia Rinnofner, Anton Glieder, Xavier Garcia-Ortega
Published 2021-04-01

Bioprocess performance analysis of novel methanol-independent promoters for recombinant protein production with Pichia pastoris

by Javier Garrigós-Martínez, Kiira Vuoristo, Miguel Angel Nieto-Taype, Juha Tähtiharju, Jaana Uusitalo, Pauliina Tukiainen, Christian Schmid, Ilya Tolstorukov, Knut Madden, Merja Penttilä, José Luis Montesinos-Seguí, Francisco Valero, Anton Glieder, Xavier Garcia-Ortega
Published 2021-03-01