Translocation Breakpoints Preferentially Occur in Euchromatin and Acrocentric Chromosomes

by Cheng-Yu Lin, Ankit Shukla, John P. Grady, J. Lynn Fink, Eloise Dray, Pascal H.G. Duijf
Published 2018-01-01

Accurate measurement of mitochondrial DNA deletion level and copy number differences in human skeletal muscle.

by John P Grady, Julie L Murphy, Emma L Blakely, Ronald G Haller, Robert W Taylor, Doug M Turnbull, Helen A L Tuppen
Published 2014-01-01

Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology

by Frank P. Lin, Subotheni Thavaneswaran, John P. Grady, Mandy Ballinger, Maya Kansara, Samantha R. Oakes, Jayesh Desai, Chee Khoon Lee, John Simes, David M. Thomas
Published 2021-06-01

Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutation...

by Laura C Greaves, Joanna L Elson, Marco Nooteboom, John P Grady, Geoffrey A Taylor, Robert W Taylor, John C Mathers, Thomas B L Kirkwood, Doug M Turnbull
Published 2012-01-01

Skeletal muscle mitochondrial oxidative phosphorylation function in idiopathic pulmonary arterial hypertension: in vivo and in vitro study

by Sasiharan Sithamparanathan, Mariana C. Rocha, Jehill D. Parikh, Karolina A. Rygiel, Gavin Falkous, John P. Grady, Kieren G. Hollingsworth, Michael I. Trenell, Robert W. Taylor, Doug M. Turnbull, Gráinne S. Gorman, Paul A. Corris
Published 2018-05-01

Chromosome arm aneuploidies shape tumour evolution and drug response

by Ankit Shukla, Thu H. M. Nguyen, Sarat B. Moka, Jonathan J. Ellis, John P. Grady, Harald Oey, Alexandre S. Cristino, Kum Kum Khanna, Dirk P. Kroese, Lutz Krause, Eloise Dray, J. Lynn Fink, Pascal H. G. Duijf
Published 2020-01-01

mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease

by John P Grady, Sarah J Pickett, Yi Shiau Ng, Charlotte L Alston, Emma L Blakely, Steven A Hardy, Catherine L Feeney, Alexandra A Bright, Andrew M Schaefer, Gráinne S Gorman, Richard JQ McNally, Robert W Taylor, Doug M Turnbull, Robert McFarland
Published 2018-06-01