Editorial: Immune Surveillance of the HIV Reservoir: Mechanisms, Therapeutic Targeting and New Avenues for HIV Cure

by Julia G. Prado, Julia G. Prado, John Frater, John Frater
Published 2020-01-01

Virus Immune Evasion: New Mechanism and Implications in Disease Outcome

by Rika Draenert, John Frater, Julia G. Prado
Published 2012-01-01

Managing outbreaks of highly contagious diseases in prisons: a systematic review

by Daniel Whiting, Seena Fazel, Babak Javid, Gabrielle Beaudry, Shaoling Zhong, John Frater
Published 2020-11-01

Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse

by James H. Felce, Lucia Parolini, Erdinc Sezgin, Erdinc Sezgin, Pablo F. Céspedes, Kseniya Korobchevskaya, Mathew Jones, Yanchun Peng, Yanchun Peng, Tao Dong, Tao Dong, Marco Fritzsche, Marco Fritzsche, Dirk Aarts, John Frater, John Frater, Michael L. Dustin
Published 2021-01-01

Modelling the evolution and spread of HIV immune escape mutants.

by Helen R Fryer, John Frater, Anna Duda, Mick G Roberts, SPARTAC Trial Investigators, Rodney E Phillips, Angela R McLean
Published 2010-11-01

CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA

by Genevieve E. Martin, Matthew Pace, John P. Thornhill, John P. Thornhill, Chansavath Phetsouphanh, Jodi Meyerowitz, Morgane Gossez, Helen Brown, Natalia Olejniczak, Julianne Lwanga, Gita Ramjee, Pontiano Kaleebu, Kholoud Porter, Christian B. Willberg, Christian B. Willberg, Paul Klenerman, Paul Klenerman, Nneka Nwokolo, Julie Fox, Sarah Fidler, John Frater, John Frater
Published 2018-05-01

Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function.

by Matthew Pace, James Williams, Ayako Kurioka, Andrew B Gerry, Bent Jakobsen, Paul Klenerman, Nneka Nwokolo, Julie Fox, Sarah Fidler, John Frater, CHERUB Investigators
Published 2016-08-01

Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers

by Chansavath Phetsouphanh, Daniel Aldridge, Emanuele Marchi, C. Mee Ling Munier, Jodi Meyerowitz, Lyle Murray, Cloete Van Vuuren, Dominique Goedhals, Sarah Fidler, Anthony Kelleher, Paul Klenerman, John Frater
Published 2019-08-01

Duration of HIV-1 viral suppression on cessation of antiretroviral therapy in primary infection correlates with time on therapy.

by Wolfgang Stöhr, Sarah Fidler, Myra McClure, Jonathan Weber, David Cooper, Gita Ramjee, Pontiano Kaleebu, Giuseppe Tambussi, Mauro Schechter, Abdel Babiker, Rodney E Phillips, Kholoud Porter, John Frater
Published 2013-01-01

Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral Therapy

by Genevieve E. Martin, Genevieve E. Martin, Debattama R. Sen, Debattama R. Sen, Matthew Pace, Nicola Robinson, Jodi Meyerowitz, Emily Adland, John P. Thornhill, John P. Thornhill, Mathew Jones, Ane Ogbe, Lucia Parolini, Natalia Olejniczak, Panagiota Zacharopoulou, Helen Brown, Christian B. Willberg, Christian B. Willberg, Nneka Nwokolo, Julie Fox, Julie Fox, Sarah Fidler, Sarah Fidler, W. Nicholas Haining, W. Nicholas Haining, John Frater, John Frater
Published 2021-06-01

Structured observations reveal slow HIV-1 CTL escape.

by Hannah E Roberts, Jacob Hurst, Nicola Robinson, Helen Brown, Peter Flanagan, Laura Vass, Sarah Fidler, Jonathan Weber, Abdel Babiker, Rodney E Phillips, Angela R McLean, John Frater, SPARTAC trial investigators
Published 2015-02-01

Mapping the drivers of within-host pathogen evolution using massive data sets

by Duncan S. Palmer, Isaac Turner, Sarah Fidler, John Frater, Dominique Goedhals, Philip Goulder, Kuan-Hsiang Gary Huang, Annette Oxenius, Rodney Phillips, Roger Shapiro, Cloete van Vuuren, Angela R. McLean, Gil McVean
Published 2019-07-01

Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment

by Cory H. White, Nadejda Beliakova-Bethell, Nadejda Beliakova-Bethell, Steven M. Lada, Michael S. Breen, Tara P. Hurst, Celsa A. Spina, Celsa A. Spina, Douglas D. Richman, Douglas D. Richman, Douglas D. Richman, John Frater, Gkikas Magiorkinis, Christopher H. Woelk
Published 2018-04-01

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.

by Matthias Hoffmann, Nikos Pantazis, Genevieve E Martin, Stephen Hickling, Jacob Hurst, Jodi Meyerowitz, Christian B Willberg, Nicola Robinson, Helen Brown, Martin Fisher, Sabine Kinloch, Abdel Babiker, Jonathan Weber, Nneka Nwokolo, Julie Fox, Sarah Fidler, Rodney Phillips, John Frater, SPARTAC and CHERUB Investigators
Published 2016-07-01

HIV-1 DNA predicts disease progression and post-treatment virological control

by James P Williams, Jacob Hurst, Wolfgang Stöhr, Nicola Robinson, Helen Brown, Martin Fisher, Sabine Kinloch, David Cooper, Mauro Schechter, Giuseppe Tambussi, Sarah Fidler, Mary Carrington, Abdel Babiker, Jonathan Weber, Kersten K Koelsch, Anthony D Kelleher, Rodney E Phillips, John Frater, on behalf of the SPARTAC trial investigators
Published 2014-09-01

Co-operative additive effects between HLA alleles in control of HIV-1.

by Philippa C Matthews, Jennifer Listgarten, Jonathan M Carlson, Rebecca Payne, Kuan-Hsiang Gary Huang, John Frater, Dominique Goedhals, Dewald Steyn, Cloete van Vuuren, Paolo Paioni, Pieter Jooste, Anthony Ogwu, Roger Shapiro, Zenele Mncube, Thumbi Ndung'u, Bruce D Walker, David Heckerman, Philip J R Goulder
Published 2012-01-01

Evaluation of Viremia Frequencies of a Novel Human Pegivirus by Using Bioinformatic Screening and PCR

by David Bonsall, William F. Gregory, Camilla L.C. Ip, Sharyne Donfield, James Iles, M. Azim Ansari, Paolo Piazza, Amy Trebes, Anthony Brown, John Frater, Oliver G. Pybus, Phillip Goulder, Paul Klenerman, Rory Bowden, Edward D. Gomperts, Eleanor Barnes, Amit Kapoor, Colin P. Sharp, Peter Simmonds
Published 2016-04-01

No evidence of neuronal damage as measured by neurofilament light chain in a HIV cure study utilising a kick-and-kill approach

by Jasmini Alagaratnam, Wolfgang Stöhr, Jamie Toombs, Amanda Heslegrave, Henrik Zetterberg, Magnus Gisslén, Sarah Pett, Mark Nelson, Amanda Clarke, Nneka Nwokolo, Margaret A. Johnson, Maryam Khan, Tomas Hanke, Jakub Kopycinski, Lucy Dorrell, Julie Fox, Sabine Kinloch, Jonathan Underwood, Matthew Pace, John Frater, Alan Winston, Sarah Fidler
Published 2021-09-01

Progression to AIDS in South Africa is associated with both reverting and compensatory viral mutations.

by Kuan-Hsiang Gary Huang, Dominique Goedhals, Jonathan M Carlson, Mark A Brockman, Swati Mishra, Zabrina L Brumme, Stephen Hickling, Christopher S W Tang, Toshiyuki Miura, Chris Seebregts, David Heckerman, Thumbi Ndung'u, Bruce Walker, Paul Klenerman, Dewald Steyn, Philip Goulder, Rodney Phillips, Bloemfontein-Oxford Collaborative Group, Cloete van Vuuren, John Frater
Published 2011-04-01

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.

by Emily Adland, Paolo Paioni, Christina Thobakgale, Leana Laker, Luisa Mori, Maximilian Muenchhoff, Anna Csala, Margaret Clapson, Jacquie Flynn, Vas Novelli, Jacob Hurst, Vanessa Naidoo, Roger Shapiro, Kuan-Hsiang Gary Huang, John Frater, Andrew Prendergast, Julia G Prado, Thumbi Ndung'u, Bruce D Walker, Mary Carrington, Pieter Jooste, Philip J R Goulder
Published 2015-06-01