Molecular insight into the autoinhibition of a master regulator of lipid signalling in human disease

by John E. Burke
Published 2020-02-01

Molecular Mechanisms of Human Disease Mediated by Oncogenic and Primary Immunodeficiency Mutations in Class IA Phosphoinositide 3-Kinases

by Gillian L. Dornan, John E. Burke
Published 2018-03-01

Phospholipase A2 structure/function, mechanism, and signaling1

by John E. Burke, Edward A. Dennis
Published 2009-01-01

Crystal structure of an archaeal CorB magnesium transporter

by Yu Seby Chen, Guennadi Kozlov, Brandon E. Moeller, Ahmed Rohaim, Rayan Fakih, Benoît Roux, John E. Burke, Kalle Gehring
Published 2021-06-01

Crystal structure of a lipin/Pah phosphatidic acid phosphatase

by Valerie I. Khayyo, Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue, Michael V. Airola
Published 2020-03-01

Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase

by Valerie I. Khayyo, Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue, Michael V. Airola
Published 2020-04-01

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

by Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke
Published 2021-03-01

An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S]

by Michael J. Pulkoski-Gross, Meredith L. Jenkins, Jean-Philip Truman, Mohamed F. Salama, Christopher J. Clarke, John E. Burke, Yusuf A. Hannun, Lina M. Obeid
Published 2018-03-01

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.

by Romy Walser, John E Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L Williams, Muriel Laffargue, Matthias P Wymann
Published 2013-01-01

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

by Meredith L. Jenkins, Jean Piero Margaria, Jordan T. B. Stariha, Reece M. Hoffmann, Jacob A. McPhail, David J. Hamelin, Martin J. Boulanger, Emilio Hirsch, John E. Burke
Published 2018-09-01

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

by Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V. Airola
Published 2021-10-01

The middle lipin domain adopts a membrane-binding dimeric protein fold

by Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola
Published 2021-08-01

Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

by Thomas Bohnacker, Andrea E. Prota, Florent Beaufils, John E. Burke, Anna Melone, Alison J. Inglis, Denise Rageot, Alexander M. Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Díaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann
Published 2017-03-01