Improved Histone Deacetylase Inhibitors as Therapeutics for the Neurodegenerative Disease Friedreich’s Ataxia: A New Synthetic Route

by Joel M. Gottesfeld, James R. Rusche, Elisabetta Soragni, Vincent Jacques, Chunping Xu
Published 2011-12-01

Mechanism of action of 2-aminobenzamide HDAC inhibitors in reversing gene silencing in Friedreich’s ataxia

by Elisabetta eSoragni, C. James Chou, James R. Rusche, Joel M. Gottesfeld
Published 2015-03-01

The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice.

by Haiqun Jia, Ying Wang, Charles D Morris, Vincent Jacques, Joel M Gottesfeld, James R Rusche, Elizabeth A Thomas
Published 2016-01-01

Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.

by Myriam Rai, Elisabetta Soragni, C James Chou, Glenn Barnes, Steve Jones, James R Rusche, Joel M Gottesfeld, Massimo Pandolfo
Published 2010-01-01

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.

by Myriam Rai, Elisabetta Soragni, Kai Jenssen, Ryan Burnett, David Herman, Giovanni Coppola, Daniel H Geschwind, Joel M Gottesfeld, Massimo Pandolfo
Published 2008-01-01

Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.

by C James Chou, Thomas O'Hare, Sophie Lefebvre, David Alvarez, Jeffrey W Tyner, Christopher A Eide, Brian J Druker, Joel M Gottesfeld
Published 2008-01-01

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

by Chiranjeevi Sandi, Ricardo Mouro Pinto, Sahar Al-Mahdawi, Vahid Ezzatizadeh, Glenn Barnes, Steve Jones, James R. Rusche, Joel M. Gottesfeld, Mark A. Pook
Published 2011-06-01

Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease

by Haiqun Jia, Judit Pallos, Vincent Jacques, Alice Lau, Bin Tang, Andrew Cooper, Adeela Syed, Judith Purcell, Yi Chen, Shefali Sharma, Gavin R. Sangrey, Shayna B. Darnell, Heather Plasterer, Ghazaleh Sadri-Vakili, Joel M. Gottesfeld, Leslie M. Thompson, James R. Rusche, J. Lawrence Marsh, Elizabeth A. Thomas
Published 2012-05-01