Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.

by Amy V Pointon, Tracy M Walker, Kate M Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D Parry, Jonathan J Lyon, Emma L Marczylo, Timothy W Gant
Published 2010-09-01

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs

by Piotr J. Kamola, Klio Maratou, Paul A. Wilson, Kay Rush, Tanya Mullaney, Tom McKevitt, Paula Evans, Jim Ridings, Probash Chowdhury, Aude Roulois, Ann Fairchild, Sean McCawley, Karen Cartwright, Nigel J. Gooderham, Timothy W. Gant, Kitty Moores, Stephen A. Hughes, Mark R. Edbrooke, Kenneth Clark, Joel D. Parry
Published 2017-09-01