Advancing Our Understanding of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms and Future Therapeutics

by Emily Greenan, Sophie Gallagher, Rana Khalil, Conor C. Murphy, Joan Ní Gabhann-Dromgoole
Published 2021-09-01

TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms.

by Elisa Lazzari, Justyna Korczeniewska, Joan Ní Gabhann, Siobhán Smith, Betsy J Barnes, Caroline A Jefferies
Published 2014-01-01

Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction

by David Shahnazaryan, Rana Khalil, Claire Wynne, Caroline A. Jefferies, Joan Ní Gabhann-Dromgoole, Conor C. Murphy
Published 2020-12-01

Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

by Rowan Higgs, Elisa Lazzari, Claire Wynne, Joan Ní Gabhann, Alexander Espinosa, Marie Wahren-Herlenius, Caroline A Jefferies
Published 2010-01-01

Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease

by Jennifer C. Byrne, Joan Ní Gabhann, Elisa Lazzari, Rebecca Mahony, Siobhán Smith, Kevin Stacey, Claire Wynne, Caroline A. Jefferies
Published 2012-01-01

Systemic IL-1β production as a consequence of corneal HSV-1 infection-contribution to the development of herpes simplex keratitis

by Joan Ní Gabhann-Dromgoole, Ciaran de Chaumont, David Shahnazaryan, Siobhán Smith, Conor Malone, Jaythoon Hassan, Cillian F. De Gascun, Caroline A. Jefferies, Conor C. Murphy
Published 2019-09-01

Btk regulates macrophage polarization in response to lipopolysaccharide.

by Joan Ní Gabhann, Emily Hams, Siobhán Smith, Claire Wynne, Jennifer C Byrne, Kiva Brennan, Shaun Spence, Adrien Kissenpfennig, James A Johnston, Padraic G Fallon, Caroline A Jefferies
Published 2014-01-01

TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.

by Claire Wynne, Elisa Lazzari, Siobhán Smith, Eoghan M McCarthy, Joan Ní Gabhann, Lara E Kallal, Rowan Higgs, Angela Greco, Sally Ann Cryan, Christine A Biron, Caroline A Jefferies
Published 2014-01-01

Investigation of type I interferon responses in ANCA-associated vasculitis

by Isabella Batten, Mark W. Robinson, Arthur White, Cathal Walsh, Barbara Fazekas, Jason Wyse, Antonia Buettner, Suzanne D’Arcy, Emily Greenan, Conor C. Murphy, Zoe Wigston, Joan Ní Gabhann-Dromgoole, Edward M. Vital, Mark A. Little, Nollaig M. Bourke
Published 2021-04-01