Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

by João V Rodrigues, Eugene I Shakhnovich
Published 2019-10-01

Development of antibacterial compounds that constrain evolutionary pathways to resistance

by Yanmin Zhang, Sourav Chowdhury, João V Rodrigues, Eugene Shakhnovich
Published 2021-07-01

Ethylmalonic encephalopathy ETHE1 R163W/R163Q mutations alter protein stability and redox properties of the iron centre.

by Bárbara J Henriques, Tânia G Lucas, João V Rodrigues, Jane H Frederiksen, Miguel S Teixeira, Valeria Tiranti, Peter Bross, Cláudio M Gomes
Published 2014-01-01

Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

by Eili Y. Klein, Deena Blumenkrantz, Adrian Serohijos, Eugene Shakhnovich, Jeong-Mo Choi, João V. Rodrigues, Brendan D. Smith, Andrew P. Lane, Andrew Feldman, Andrew Pekosz, W. Paul Duprex, Christopher Brooke, Feng Ding
Published 2018-01-01