Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren’s Syndrome Patients Identifies CCL5 as a Novel Effector Molecule

by Anneline C. Hinrichs, Anneline C. Hinrichs, Sofie L. M. Blokland, Sofie L. M. Blokland, Ana P. Lopes, Ana P. Lopes, Catharina G. K. Wichers, Catharina G. K. Wichers, Aike A. Kruize, Aridaman Pandit, Aridaman Pandit, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Joel A. G. van Roon, Joel A. G. van Roon
Published 2021-07-01

The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade.

by Maarten R Hillen, Sarita A Y Hartgring, Cynthia R Willis, Timothy R D J Radstake, Cornelis E Hack, Floris P J G Lafeber, Joel A G van Roon
Published 2015-01-01

The Transcriptomic Profile of Monocytes from Patients With Sjögren’s Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators

by Ana P. Lopes, Ana P. Lopes, Cornelis P. J. Bekker, Cornelis P. J. Bekker, Maarten R. Hillen, Maarten R. Hillen, Sofie L. M. Blokland, Sofie L. M. Blokland, Anneline C. Hinrichs, Anneline C. Hinrichs, Aridaman Pandit, Aridaman Pandit, Aike A. Kruize, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Joel A. G. van Roon, Joel A. G. van Roon
Published 2021-08-01

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I...

by Timothy R D J Radstake, Joel A G van Roon, Maarten R Hillen, Sofie L M Blokland, Aridaman Pandit, Katia Urso, Emma Koppe, Ana Pinheiro Lopes, Tom Slocombe, André van Maurik
Published 2020-08-01

Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjögren's syndrome.

by Ana P Lopes, Maarten R Hillen, Eleni Chouri, Sofie L M Blokland, Cornelis P J Bekker, Aike A Kruize, Marzia Rossato, Joel A G van Roon, Timothy R D J Radstake
Published 2018-01-01

Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation.

by Angela Bikker, Aike A Kruize, Kim M G van der Wurff-Jacobs, Rogier P Peters, Marije Kleinjan, Frank Redegeld, Wilco de Jager, Floris P J G Lafeber, Joël A G van Roon
Published 2014-01-01

MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1

by Ana P. Lopes, Ana P. Lopes, Joel A. G. van Roon, Joel A. G. van Roon, Sofie L. M. Blokland, Sofie L. M. Blokland, Maojie Wang, Eleni Chouri, Eleni Chouri, Sarita A. Y. Hartgring, Sarita A. Y. Hartgring, Kim M. G. van der Wurff-Jacobs, Aike A. Kruize, Boudewijn M. T. Burgering, Marzia Rossato, Marzia Rossato, Marzia Rossato, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Maarten R. Hillen, Maarten R. Hillen
Published 2019-06-01

Plasmacytoid DCs From Patients With Sjögren's Syndrome Are Transcriptionally Primed for Enhanced Pro-inflammatory Cytokine Production

by Maarten R. Hillen, Maarten R. Hillen, Aridaman Pandit, Aridaman Pandit, Sofie L. M. Blokland, Sofie L. M. Blokland, Sarita A. Y. Hartgring, Sarita A. Y. Hartgring, Cornelis P. J. Bekker, Cornelis P. J. Bekker, Eefje H. M. van der Heijden, Eefje H. M. van der Heijden, Nila H. Servaas, Nila H. Servaas, Marzia Rossato, Marzia Rossato, Marzia Rossato, Aike A. Kruize, Joel A. G. van Roon, Joel A. G. van Roon, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake
Published 2019-09-01

Implication of miR-126 and miR-139-5p in Plasmacytoid Dendritic Cell Dysregulation in Systemic Sclerosis

by Eleni Chouri, Maojie Wang, Maarten R. Hillen, Chiara Angiolilli, Sandra C. Silva-Cardoso, Catharina G.K. Wichers, Maarten van der Kroef, Cornelis P.J. Bekker, Marta Cossu, Lenny van Bon, Alsya J. Affandi, Tiago Carvalheiro, Aridaman Pandit, Joel A.G. van Roon, Lorenzo Beretta, Boudewijn M. T. Burgering, Timothy R.D.J. Radstake, Marzia Rossato
Published 2021-01-01