Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming

by Xiaowei Lai, Xiaowei Lai, Xiaowei Lai, Qian Li, Qian Li, Qian Li, Fang Wu, Fang Wu, Fang Wu, Jiechun Lin, Jiechun Lin, Jiechun Lin, Jiekai Chen, Jiekai Chen, Jiekai Chen, Jiekai Chen, Hui Zheng, Hui Zheng, Hui Zheng, Hui Zheng, Lin Guo, Lin Guo, Lin Guo, Lin Guo
Published 2020-08-01

Mouse embryonic stem cells resist c-Jun induced differentiation when in suspension

by Bo Wang, Dongwei Li, Jiekai Chen, Jing Liu, Duanqing Pei
Published 2018-09-01

DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner

by Yawei Song, Yawei Song, Yawei Song, Yawei Song, Yawei Song, Gongcheng Hu, Gongcheng Hu, Gongcheng Hu, Gongcheng Hu, Jinping Jia, Mingze Yao, Xiaoshan Wang, Wenliang Lu, Andrew P. Hutchins, Jiekai Chen, Jiekai Chen, Jiekai Chen, Keiko Ozato, Hongjie Yao, Hongjie Yao, Hongjie Yao, Hongjie Yao
Published 2020-12-01

Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells

by Fangxiao Hu, Dehao Huang, Yuxuan Luo, Peiqing Zhou, Cui Lv, Kaitao Wang, Qitong Weng, Yuxian Guan, Jiekai Chen, Jinyong Wang, Hongling Wu
Published 2020-07-01

Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE

by Jiangping He, Isaac A. Babarinde, Li Sun, Shuyang Xu, Ruhai Chen, Junjie Shi, Yuanjie Wei, Yuhao Li, Gang Ma, Qiang Zhuang, Andrew P. Hutchins, Jiekai Chen
Published 2021-03-01

SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States

by Kaixin Wu, He Liu, Yaofeng Wang, Jiangping He, Shuyang Xu, Yaping Chen, Junqi Kuang, Jiadong Liu, Lin Guo, Dongwei Li, Ruona Shi, Li Shen, Yangming Wang, Xiaofei Zhang, Jie Wang, Duanqing Pei, Jiekai Chen
Published 2020-01-01

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells

by Xuejia Li, Chengxiang Xia, Tongjie Wang, Lijuan Liu, Qianhao Zhao, Dan Yang, Fangxiao Hu, Mengyun Zhang, Ke Huang, Yang Geng, Yi Zheng, Yuxian Guan, Hongling Wu, Xiaoli Chen, Guangjin Pan, Jiekai Chen, Juan Du, Jinyong Wang
Published 2017-05-01

OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo

by Xiaoli Chen, Qianhao Zhao, Chen Li, Yang Geng, Ke Huang, Jian Zhang, Xiaoshan Wang, Jiaqi Yang, Tongjie Wang, Chengxiang Xia, Xiaofei Liu, Minghui Meng, Dan Yang, Yi Zheng, Juan Du, Xiangzhong Zhang, Jiekai Chen, Guangjin Pan, Jinyong Wang
Published 2015-09-01

Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells

by Jiangping He, Xiuling Fu, Meng Zhang, Fangfang He, Wenjuan Li, Mazid Md. Abdul, Jianguo Zhou, Li Sun, Chen Chang, Yuhao Li, He Liu, Kaixin Wu, Isaac A. Babarinde, Qiang Zhuang, Yuin-Han Loh, Jiekai Chen, Miguel A. Esteban, Andrew P. Hutchins
Published 2019-01-01

Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2

by Vikas Malik, Laura V. Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A. Esteban, Huating Wang, Jiekai Chen, Hans R. Schöler, Andrew P. Hutchins, Sebastiaan H. Meijsing, Sebastian Pott, Ralf Jauch
Published 2019-08-01

Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo

by Songwei He, Yiping Guo, Yixin Zhang, Yuan Li, Chengqian Feng, Xiang Li, Lilong Lin, Lin Guo, Haitao Wang, Chunhua Liu, Yi Zheng, Chuanming Luo, Qiang Liu, Fuhui Wang, Hao Sun, Lining Liang, Lingyu Li, Huanxing Su, Jiekai Chen, Duanqing Pei, Hui Zheng
Published 2015-01-01

Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function

by Zhiwei Zhou, Xuejie Yang, Jiangping He, Jing Liu, Fang Wu, Shengyong Yu, Yuting Liu, Runxia Lin, He Liu, Yuanbin Cui, Chunhua Zhou, Xiaoshan Wang, Jian Wu, Shangtao Cao, Lin Guo, Lihui Lin, Tao Wang, Xiaozhong Peng, Boqing Qiang, Andrew P. Hutchins, Duanqing Pei, Jiekai Chen
Published 2017-11-01

Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients

by Jiangping He, Shuijiang Cai, Huijian Feng, Baomei Cai, Lihui Lin, Yuanbang Mai, Yinqiang Fan, Airu Zhu, Huang Huang, Junjie Shi, Dingxin Li, Yuanjie Wei, Yueping Li, Yingying Zhao, Yuejun Pan, He Liu, Xiaoneng Mo, Xi He, Shangtao Cao, FengYu Hu, Jincun Zhao, Jie Wang, Nanshan Zhong, Xinwen Chen, Xilong Deng, Jiekai Chen
Published 2020-07-01

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4

by Bo Wang, Linlin Wu, Dongwei Li, Yuting Liu, Jing Guo, Chen Li, Yuxiang Yao, Yaofeng Wang, Guoqing Zhao, Xiaoshan Wang, Meijun Fu, He Liu, Shangtao Cao, Chuman Wu, Shengyong Yu, Chunhua Zhou, Yue Qin, Junqi Kuang, Jin Ming, Shilong Chu, Xuejie Yang, Ping Zhu, Guangjin Pan, Jiekai Chen, Jing Liu, Duanqing Pei
Published 2019-06-01

XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer

by Degong Ruan, Jiangyun Peng, Xiaoshan Wang, Zhen Ouyang, Qingjian Zou, Yi Yang, Fangbing Chen, Weikai Ge, Han Wu, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Chengdan Lai, Nana Fan, Zhiwei Zhou, Qishuai Liu, Nan Li, Qin Jin, Hui Shi, Jingke Xie, Hong Song, Xiaoyu Yang, Jiekai Chen, Kepin Wang, Xiaoping Li, Liangxue Lai
Published 2018-02-01

SS18 regulates pluripotent-somatic transition through phase separation

by Junqi Kuang, Ziwei Zhai, Pengli Li, Ruona Shi, Wenjing Guo, Yuxiang Yao, Jing Guo, Guoqing Zhao, Jiangpin He, Shuyang Xu, Chuman Wu, Shengyong Yu, Chunhua Zhou, Linlin Wu, Yue Qin, Baomei Cai, Wei Li, Zichao Wu, Xiaoxi Li, Shilong Chu, Tingting Yang, Bo Wang, Shangtao Cao, Dongwei Li, Xiaofei Zhang, Jiekai Chen, Jing Liu, Duanqing Pei
Published 2021-07-01

PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs

by Yongli Shan, Zechuan Liang, Qi Xing, Tian Zhang, Bo Wang, Shulan Tian, Wenhao Huang, Yanqi Zhang, Jiao Yao, Yanling Zhu, Ke Huang, Yujian Liu, Xiaoshan Wang, Qianyu Chen, Jian Zhang, Bizhi Shang, Shengbiao Li, Xi Shi, Baojian Liao, Cong Zhang, Keyu Lai, Xiaofen Zhong, Xiaodong Shu, Jinyong Wang, Hongjie Yao, Jiekai Chen, Duanqing Pei, Guangjin Pan
Published 2017-09-01

BMI1 enables interspecies chimerism with human pluripotent stem cells

by Ke Huang, Yanling Zhu, Yanlin Ma, Bentian Zhao, Nana Fan, Yuhang Li, Hong Song, Shilong Chu, Zhen Ouyang, Quanjun Zhang, Qi Xing, Chengdan Lai, Nan Li, Tian Zhang, Jiaming Gu, Baoqiang Kang, Yongli Shan, Keyu Lai, Wenhao Huang, Yuchan Mai, Qing Wang, Jinbing Li, Aiping Lin, Yanqi Zhang, Xiaofen Zhong, Baojian Liao, Liangxue Lai, Jiekai Chen, Duanqing Pei, Guangjin Pan
Published 2018-11-01

JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency

by Yinghua Huang, Hui Zhang, Lulu Wang, Chuanqing Tang, Xiaogan Qin, Xinyu Wu, Meifang Pan, Yujia Tang, Zhongzhou Yang, Isaac A. Babarinde, Runxia Lin, Guanyu Ji, Yiwei Lai, Xueting Xu, Jianbin Su, Xue Wen, Takashi Satoh, Tanveer Ahmed, Vikas Malik, Carl Ward, Giacomo Volpe, Lin Guo, Jinlong Chen, Li Sun, Yingying Li, Xiaofen Huang, Xichen Bao, Fei Gao, Baohua Liu, Hui Zheng, Ralf Jauch, Liangxue Lai, Guangjin Pan, Jiekai Chen, Giuseppe Testa, Shizuo Akira, Jifan Hu, Duanqing Pei, Andrew P. Hutchins, Miguel A. Esteban, Baoming Qin
Published 2020-10-01