Topical Astodrimer Sodium, a Non-Toxic Polyanionic Dendrimer, Demonstrates Antiviral Activity in an Experimental Ocular Adenovirus Infection Model

by Eric G. Romanowski, Kathleen A. Yates, Jeremy R. A. Paull, Graham P. Heery, Robert M. Q. Shanks
Published 2021-06-01

Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 Mice

by Jeremy R. A. Paull, Carolyn A. Luscombe, Alex Castellarnau, Graham P. Heery, Michael D. Bobardt, Philippe A. Gallay
Published 2021-08-01

A phase I randomized placebo controlled trial of the safety of 3% SPL7013 Gel (VivaGel®) in healthy young women administered twice daily for 14 days.

by Craig R Cohen, Joelle Brown, Anna-Barbara Moscicki, Elizabeth A Bukusi, Jeremy R A Paull, Clare F Price, Stephen Shiboski
Published 2011-01-01

A phase 2, double-blind, multicenter, randomized, placebo-controlled, dose‑ranging study of the efficacy and safety of Astodrimer Gel for the treatment of bacterial vaginosis.

by Arthur S Waldbaum, Jane R Schwebke, Jeremy R A Paull, Clare F Price, Stephanie R Edmondson, Alex Castellarnau, Philip McCloud, George R Kinghorn
Published 2020-01-01

A phase 3, randomized, controlled trial of Astodrimer 1% Gel for preventing recurrent bacterial vaginosis

by Jane R. Schwebke, Belvia A. Carter, Arthur S. Waldbaum, Kathy J. Agnew, Jeremy R.A. Paull, Clare F. Price, Alex Castellarnau, Philip McCloud, George R. Kinghorn
Published 2021-04-01

SPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans.

by Clare F Price, David Tyssen, Secondo Sonza, Ashley Davie, Sonya Evans, Gareth R Lewis, Shirley Xia, Tim Spelman, Peter Hodsman, Thomas R Moench, Andrew Humberstone, Jeremy R A Paull, Gilda Tachedjian
Published 2011-01-01

Structure activity relationship of dendrimer microbicides with dual action antiviral activity.

by David Tyssen, Scott A Henderson, Adam Johnson, Jasminka Sterjovski, Katie Moore, Jennifer La, Mark Zanin, Secondo Sonza, Peter Karellas, Michael P Giannis, Guy Krippner, Steve Wesselingh, Tom McCarthy, Paul R Gorry, Paul A Ramsland, Richard Cone, Jeremy R A Paull, Gareth R Lewis, Gilda Tachedjian
Published 2010-08-01