The Plant-Derived Chalcone 2,2′,5′-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia

by Manasi Jiwrajka, Alexandra Phillips, Matt Butler, Miriam Rossi, Jennifer M. Pocock
Published 2016-01-01

Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

by Jenny Lange, Luke J. Haslett, Emyr Lloyd-Evans, Jennifer M. Pocock, Mark S. Sands, Brenda P. Williams, Jonathan D. Cooper
Published 2018-08-01

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

by Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M. Piers, James Staddon, Stephen J. Neame, John Hardy, Jennifer M. Pocock
Published 2021-06-01

Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species

by Grace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood-Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi, Ralph Andre
Published 2021-04-01

Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity

by Thomas M. Piers, Emma East, Claudio Villegas-Llerena, Claudio Villegas-Llerena, Ioanna G. Sevastou, Mar Matarin, Mar Matarin, John Hardy, Jennifer M. Pocock
Published 2018-11-01

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

by Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock, Christian Haass
Published 2018-09-01